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Medical Condition
depression disorders
Total Trials
6
Recruiting Now
6
Trial Phases
Phase 3
Depression trials address major depressive disorder (MDD), treatment-resistant depression (TRD), and postpartum depression with a growing toolkit that extends beyond conventional SSRIs/SNRIs. The rapid approval of ketamine/esketamine for TRD has sparked interest in NMDA receptor modulators, while psychedelic-assisted therapy (psilocybin, MDMA) trials represent a paradigm shift in psychiatric research.
Active trials investigate rapid-acting antidepressants (ketamine analogs), neuroactive steroids, transcranial magnetic stimulation (TMS) protocols, psychedelic-assisted psychotherapy, digital therapeutics, and precision psychiatry approaches using biomarkers or genetic testing to predict treatment response.
Depression trials typically require a minimum MADRS or HAMD score at baseline; TRD trials usually require failure of at least 2 prior adequate antidepressant courses.
Frequently Asked Questions — depression disorders Clinical Trials
How many clinical trials are currently recruiting for depression disorders?
ClinicalMetric currently tracks 6 actively recruiting clinical trials for depression disorders, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 6. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for depression disorders?
depression disorders research spans Phase 3 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a depression disorders clinical trial?
Eligibility criteria for depression disorders trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 3 1
Top Sponsors
1 trial
1 trial
1 trial
1 trial
1 trial
Recruiting Clinical Trials
NCT06793397 Phase 3
Recruiting
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Enrollment
330 pts
Location
United States, Austr...
Sponsor
Cybin IRL Limited
NCT06738953
Recruiting
Prevention of Mental Disorders Through Self-efficacy Interventions
Enrollment
378 pts
Location
Germany
Sponsor
Health and Medical University ...
NCT06722781
Recruiting
Trial of an Online Group Psychotherapy Intervention for Common Mental Health Disorders
Enrollment
660 pts
Location
United Kingdom
Sponsor
Rotherham Doncaster and South ...
NCT07152925
Recruiting
The Impact of Beta-band Transcranial Alternating Current Stimulation (tACS) on Impulse Inhibition in Adolescents With Non-suicidal Self-injury
Enrollment
60 pts
Location
China
Sponsor
Anhui Medical University
NCT07212075
Recruiting
Precision Subclassification of Mental Health in Diabetes: Digital Twins for Precision Mental Health to Track Subgroups
Enrollment
1,809 pts
Location
Germany
Sponsor
Forschungsinstitut der Diabete...
NCT06755710
Recruiting
Patient Engagement in PTSD Treatment (PEP)
Enrollment
427 pts
Location
Denmark
Sponsor
Mental Health Centre Copenhage...
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: April 2026 · Data Methodology