NCT07752355 Young Onset Parkinson's Disease Subtypes and Pathogenic Mechanisms
| NCT ID | NCT07752355 |
| Status | Recruiting |
| Phase | — |
| Sponsor | NYU Langone Health |
| Condition | Young Onset Parkinson Disease |
| Study Type | OBSERVATIONAL |
| Enrollment | 250 participants |
| Start Date | 2024-02-28 |
| Primary Completion | 2028-10-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 250 participants in total. It began in 2024-02-28 with a primary completion date of 2028-10-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Young Onset Parkinson's disease (YOPD) refers to a group of patients in which the disease starts earlier in life (before the age of 50 years) and has a profound impact on most of patient's life. Current knowledge regarding the mechanisms leading to development of Parkinson's disease in younger individuals is lacking, but their understanding is crucial for the successful design of therapeutic strategies and stratifying patients for clinical trials. With this research the investigators aim to clarify the contribution of relevant biological processes in patients with Young onset Parkinson's disease to help understanding disease mechanisms and biomarkers.
Eligibility Criteria
Inclusion Criteria: YOPD cohort: 1. Male or female 18 years or older (inclusive) of any race and ethnicity 2. Diagnosis of Parkinson's disease (PD) confirmed by a movement disorder specialist and with an age of onset of less than or equal to the age of 50 years old 3. Willingness to undergo a skin punch biopsy LOPD cohort: 1. Male or female 18 years or older (inclusive) of any race and ethnicity 2. Diagnosis of PD confirmed by a movement disorder specialist and with an age of onset after the age of 50 years Healthy Control cohort: 1. Male or female 18 years or older (inclusive) of any race and ethnicity 2. Never been diagnosed with PD as reported by medical history and as assessed by study PI Exclusion Criteria: 1. Diagnosis of atypical parkinsonism (i.e. progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy) or secondary parkinsonism (i.e. normal pressure hydrocephalus, drug-induced parkinsonism). 2. Clinical history of autoimmune or chronic inflammatory disorder or exposure to chronic immunosuppressant or immunomodulatory medications. 3. Pregnancy 4. Dermatological conditions that would prevent performing skin punch biopsies
Contact & Investigator
Giulietta Riboldi, MD, PhD
PRINCIPAL INVESTIGATOR
NYU Langone Health
Frequently Asked Questions
Who can join the NCT07752355 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Young Onset Parkinson Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07752355 currently recruiting?
Yes, NCT07752355 is actively recruiting participants. Contact the research team at Mark.Belio@nyulangone.org for enrollment information.
Where is the NCT07752355 trial being conducted?
This trial is being conducted at New York, United States.
Who is sponsoring the NCT07752355 clinical trial?
NCT07752355 is sponsored by NYU Langone Health. The principal investigator is Giulietta Riboldi, MD, PhD at NYU Langone Health. The trial plans to enroll 250 participants.
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