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Recruiting Phase 3 NCT07067866
NCT07067866 Weaning Approaches for Vasopressin in Sepsis
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| NCT ID | NCT07067866 |
| Status | Recruiting |
| Phase | Phase 3 |
| Sponsor | Hospital Nossa Senhora da Conceicao |
| Condition | Septic Shock |
| Study Type | INTERVENTIONAL |
| Enrollment | 82 participants |
| Start Date | 2025-10-01 |
| Primary Completion | 2027-12-31 |
Trial Parameters
Condition Septic Shock
Sponsor Hospital Nossa Senhora da Conceicao
Study Type INTERVENTIONAL
Phase Phase 3
Enrollment 82
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2025-10-01
Completion 2027-12-31
Interventions
Titrated weaning of vasopressin.Abrupt weaning of vasopressin.
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Brief Summary
In this study, we aim to evaluate the incidence of hypotension during vasopressin weaning by comparing two methods - titrated reduction versus abrupt withdrawal - through the conduct of a randomized clinical trial.
Eligibility Criteria
Inclusion Criteria: * Age over 18 years * Admitted to the Intensive Care Unit * Patients with vasopressor dependent sepsis * Receiving combined norepinephrine and vasopressin therapy Exclusion Criteria: * Withdrawal/reduction of vasopressin related to a plan of treatment limitation or palliative care * Withdrawal/reduction of vasopressin associated with the initiation of adrenaline or any other vasopressor
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