NCT06274112 Using TMS to Understand Neural Processes of Social Motivation
| NCT ID | NCT06274112 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Auburn University |
| Condition | Social Avoidant Behavior |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2025-09-30 |
| Primary Completion | 2029-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2025-09-30 with a primary completion date of 2029-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation. Participant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period. The first study visit involves answering survey questions, a clinical interview, and computer tasks. The second study visit involves a magnetic resonance imaging (MRI) scan, computer tasks, and a brief TMS protocol. The second and third study visits involve a full session of TMS followed by an MRI scan and computer tasks. Adults in the Auburn/Opelika area and surrounding areas who avoid social situations, experience symptoms of depression or social anxiety, and are between 25 years old and 50 years old are eligible to participate.
Eligibility Criteria
Inclusion Criteria: * A diagnosis of Major Depressive Disorder OR a diagnosis of Social Anxiety Disorder (assessed/confirmed at screening visit). * Scoring above clinical threshold on a measure of social avoidant behavior (assessed/confirmed at phone screen). Exclusion Criteria: * Unstable psychotropic medication regimen (i.e., changes in psychotropic medication or dosage in past 3 months). * Current or lifetime diagnosis of Bipolar Disorder. * A diagnosis of substance use disorder within past 12 months. * A diagnosis of psychotic-spectrum disorder such as Schizophrenia. * Pregnancy or probable pregnancy. * Medical illness or medical treatment that would preclude or inhibit study participation. * Neurological disorder associated with brain damage. * History of seizures or head trauma with loss of consciousness \> 5 minutes. * Family history of epilepsy or personal epilepsy/seizures * Ferromagnetic implants or ferrmagnetic objects within body (e.g., pacemaker).
Frequently Asked Questions
Who can join the NCT06274112 clinical trial?
This trial is open to participants of all sexes, aged 25 Years or older, up to 50 Years, studying Social Avoidant Behavior. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06274112 currently recruiting?
Yes, NCT06274112 is actively recruiting participants. Visit ClinicalTrials.gov or contact Auburn University to inquire about joining.
Where is the NCT06274112 trial being conducted?
This trial is being conducted at Auburn, United States.
Who is sponsoring the NCT06274112 clinical trial?
NCT06274112 is sponsored by Auburn University. The trial plans to enroll 40 participants.