NCT07295990 Tongue-strengthening Exercises in People With ALS.
| NCT ID | NCT07295990 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Nova Southeastern University |
| Condition | ALS (Amyotrophic Lateral Sclerosis) |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2026-05-01 |
| Primary Completion | 2028-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2026-05-01 with a primary completion date of 2028-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study is testing a tongue exercise program for people living with ALS to see if it can help support speech and swallowing. All participants will receive the treatment, and researchers will measure changes over time by comparing each person's results to their own earlier results. People who join the study will have two in-person visits and four weekly telehealth sessions with a speech-language pathologist. During these sessions, participants will practice tongue resistance exercises, complete speech and swallowing tasks, and answer surveys about their experience. They will also use a small device at home to measure tongue strength and swallowing. The exercise program involves pressing the tongue against a device several times a day, five days per week, for five weeks. Researchers want to learn if this program is safe, practical, and helpful for people with ALS.
Eligibility Criteria
Inclusion Criteria: * Diagnosis of possible, probable, or definite ALS (El-Escorial Revisited) * Lingual exercises naïve * Impaired lingual strength generation compared to normative data * EAT-10 score \<3 Exclusion Criteria: * Stroke * Head injury * Head and neck cancer * Tracheostomy * Other concomitant neurogenic disorder * Recent oral surgery other than routine dental surgery * Unable to generate isometric lingual pressure on lingual manometer * Participation in another clinical trial intervention that may confound results * NPO (nothing by mouth) * Anarthric
Contact & Investigator
Lauren Tabor Gray, Ph.D.
PRINCIPAL INVESTIGATOR
Neuroscience Institute, Cathy J. Husman ALS Center
Frequently Asked Questions
Who can join the NCT07295990 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 99 Years, studying ALS (Amyotrophic Lateral Sclerosis). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07295990 currently recruiting?
Yes, NCT07295990 is actively recruiting participants. Contact the research team at rw602@nova.edu for enrollment information.
Where is the NCT07295990 trial being conducted?
This trial is being conducted at Davie, United States.
Who is sponsoring the NCT07295990 clinical trial?
NCT07295990 is sponsored by Nova Southeastern University. The principal investigator is Lauren Tabor Gray, Ph.D. at Neuroscience Institute, Cathy J. Husman ALS Center. The trial plans to enroll 20 participants.
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