NCT07473518 Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy
| NCT ID | NCT07473518 |
| Status | Recruiting |
| Phase | — |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna |
| Condition | Thyroid Carcinoma |
| Study Type | OBSERVATIONAL |
| Enrollment | 2,550 participants |
| Start Date | 2025-07-30 |
| Primary Completion | 2026-07-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 2,550 participants in total. It began in 2025-07-30 with a primary completion date of 2026-07-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer. It also investigates the genetic features of thyroid tumors in this population to identify predictive biomarkers of onset, malignancy, and aggressiveness. Ultimately, the goal is to support more personalized management, including tailored surgery and targeted therapies.
Eligibility Criteria
INCLUSION CRITERIA For the group of oncologic patients who underwent radiotherapy: * Radiotherapy for an oncologic condition performed between January 1, 1999, and December 31, 2018; * Age at the time of radiotherapy \< 18 years; * Follow-up of at least 4 years conducted at the Endocrine-Metabolic Diseases Program, Pediatric Unit, IRCCS AOU Bologna; * Obtained informed consent For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC: * No history of exposure to ionizing radiation; * No specific risk factors for DTC (autoimmune thyroiditis, familial forms, genetic syndromes); * Thyroid ultrasound performed between January 1, 1999, and December 31, 2018, at the Nuclear Medicine Unit of IRCCS AOU Bologna; * Age at the time of the thyroid ultrasound \< 18 years; * Obtained informed consent EXCLUSION CRITERIA: For the group of oncologic patients who underwent radiotherapy: * Patients transferred to another center before completing 4 years of follow-up after radiotherapy at the Pediatric Unit of IRCCS AOU Bologna, without having received a diagnosis of thyroid cancer. For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC: * None.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07473518 clinical trial?
This trial is open to participants of all sexes, aged 10 Years or older, up to 43 Years, studying Thyroid Carcinoma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07473518 currently recruiting?
Yes, NCT07473518 is actively recruiting participants. Contact the research team at federico.baronio@aosp.bo.it for enrollment information.
Where is the NCT07473518 trial being conducted?
This trial is being conducted at Bologna, Italy, Bologna, Italy.
Who is sponsoring the NCT07473518 clinical trial?
NCT07473518 is sponsored by IRCCS Azienda Ospedaliero-Universitaria di Bologna. The trial plans to enroll 2,550 participants.