The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease
Trial Parameters
Brief Summary
The goal of this study is to clarify the role of the bacterium Cutibacterium acnes in the development of degenerative disc disease in patients with lumbar disc herniation who underwent microdiscectomy as part of their regular medical care.
Eligibility Criteria
Inclusion Criteria: * minimum age of 18 years * MRI of the lumbosacral spine performed one month ± 2weeks before surgery showing a disc protrusion, herniation, or free nucleus pulposus sequestration * matching physical examination findings including positive straight leg raise test, dermatomal sensory deficits, myotome motor deficits, and diminished deep tendon reflexes. Exclusion Criteria: * antibiotics or corticosteroid use the month before surgery * ongoing bacterial or viral infection * immunocompromised patient * trauma * undefined radiological mass * inflammatory arthritis * other rheumatologic diseases.