NCT06501222 The Renal Protective Effects of Remote Ischemic Preconditioning in Patients With Chronic Kidney Disease
| NCT ID | NCT06501222 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Yuanjun Yang |
| Condition | Chronic Kidney Diseases |
| Study Type | INTERVENTIONAL |
| Enrollment | 114 participants |
| Start Date | 2024-03-01 |
| Primary Completion | 2026-03-30 |
Trial Parameters
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Brief Summary
The incidence of Chronic kidney disease (CKD) is showing an upward trend, but the therapeutic effect of treatment is limited. Remote ischemic conditioning (RIC) has the potential to safeguard remote organs via the repeated application of brief ischemic stimuli. the aim of our study is to investigate whether RIC can protect the renal function in patients with CKD.
Eligibility Criteria
Inclusion Criteria: 1. CKD Patients with eGFR ≥ 15ml/min/1.73m2 2. Age ≥ 18 years old 3. 24-hour urine protein excretion ≤ 3.5g 4. Subjects who have signed the informed consent form Exclusion Criteria: 1. Patients with nephrotic syndrome 2. Patients with acute kidney injury 3. Patients who have undergone renal replacement treatment in the past 4. Patients who may have medication changes during RIC or sham-RIC intervention 5. Patients with a history of diabetes or glycated hemoglobin \> 8% 6. Patients with familial hypercholesterolemia (\>5.5 mmol/L) accompanied by high low-density lipoprotein (\>2.5 mmol/L) 7. Patients with contraindications to RIC, such as vascular injury, soft tissue injury, fracture, infection, or known peripheral vascular disease in both arms 8. Patients with a history of hemostatic disorders, systemic bleeding, or thrombocytopenia 9. Patients with cardiogenic embolism (atrial fibrillation) or other severe arrhythmias (severe bradycardia, third-degree atrioventricu
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