NCT07025070 The Link Between Physical Activity and Brain Health in Healthy Adults

Trial Parameters

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Brief Summary

The goal of this observational study is to investigate the cross-sectional relationship between physical activity and brain health from a multiscale approach (neuropsychology, neuroimaging, peripheral biomarkers and genetics) in former athletes and sedentary individuals. The main question it aims to answer is: Do former athletes have better brain structure than sedentary people? Evaluating the differences in neurodegenerative processes between competitive training and sedentary and inactivity.

Eligibility Criteria

Inclusion Criteria: * Group A: ex-athletes and continue to perform regular physical exercise (minimum 3 days/week of moderate-vigorous intensity). * Group B: sedentary individuals, (i.e., perform \<150 min of moderate intensity exercise per week or IPAQ score\<600 MET min/week). * In both groups (A and B) the conditions of physical exercise or sedentary lifestyle must have been maintained for at least 6 months prior to the evaluations. * Not having a history of neurological or psychiatric disorder or suffering from a serious medical condition Exclusion Criteria: * Medical conditions that have a high risk of associated cognitive symptoms. * Severe head injury with loss of consciousness within the previous 5 years. * Alcoholism (\>3 alcoholic drinks per day). * Chronic use of anxiolytics, neuroleptics, narcotics, anticonvulsants, or sedative hypnotics. * Hearing or visual impairment that would preclude testing * History of neurological disease with clinically relevant impact on cognition

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