NCT07531732 Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases
| NCT ID | NCT07531732 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Condition | Frontotemporal Dementia, Behavioral Variant |
| Study Type | OBSERVATIONAL |
| Enrollment | 34 participants |
| Start Date | 2026-04 |
| Primary Completion | 2027-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 34 participants in total. It began in 2026-04 with a primary completion date of 2027-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This monocentric, non-interventional study (SELFSOC) investigates the relationship between self-awareness and social cognition in patients with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). The primary objective is to assess metacognitive efficiency related to social cognitive performance using a computerized facial emotion recognition task combined with confidence judgments. Metacognitive indices (including Mratio) will quantify the correspondence between subjective and objective performance. Thirty-four participants (17 bvFTD, 17 AD; age 50-80; MMSE ≥20) will complete two study visits involving tasks assessing emotion recognition, theory of mind, and memory.
Eligibility Criteria
Inclusion Criteria: * Diagnosis of possible or probable behavioral variant frontotemporal dementia according to the Rascovsky 2011 criteria (DLFTvc group) OR * Diagnosis of Alzheimer's disease according to the Jack 2018 criteria, including biomarkers (MA group) * Mini-Mental State Examination (MMSE) ≥ 20 * Age: 50-80 years * Sufficient reading and writing proficiency in French to enable completion of the study procedures, in the investigator's opinion Exclusion Criteria: * Moderate to severe language disorders: Confrontation naming (DO 40 scale) ≤ 32 * Inability to perform computerized tasks according to the investigator's opinion * Other neurological disorders (including epilepsy, Lewy body disease, vascular dementia) * Psychiatric comorbidities (bipolar disorder, schizophrenia, current major depressive episode) * Uncorrected visual impairment
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07531732 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 80 Years, studying Frontotemporal Dementia, Behavioral Variant. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07531732 currently recruiting?
Yes, NCT07531732 is actively recruiting participants. Contact the research team at emmanuel.cognat@aphp.fr for enrollment information.
Where is the NCT07531732 trial being conducted?
This trial is being conducted at Paris, France.
Who is sponsoring the NCT07531732 clinical trial?
NCT07531732 is sponsored by Assistance Publique - Hôpitaux de Paris. The trial plans to enroll 34 participants.