The Impact of Daily Intake of Short-chain Fatty Acids on Cardiometabolic Risk Factors in Individuals at Risk for Metabolic Syndrome
This study examines whether taking short-chain fatty acids daily can improve heart and metabolic health in people at risk for metabolic syndrome. Researchers will measure changes in blood fat and sugar levels, weight, blood pressure, and how many calories your body burns.
Key Objective: The trial tests whether short-chain fatty acids can reduce cardiometabolic risk factors and improve metabolic health in at-risk individuals.
Who to Consider: People who are at risk for metabolic syndrome or concerned about their cardiovascular and metabolic health should consider enrolling.
Trial Parameters
Brief Summary
During this study, the effect of short-chain fatty acids on blood lipaedemia, glycemia, anthropometrics, blood pressure and energy expenditure will be investigated.
Eligibility Criteria
Inclusion Criteria: * male and female participants * central obesity ( BMI ≥ 25 kg/m² or waist circumference ≥ 80 cm for women/ ≥ 94 cm for men) * One additional risk factor for metabolic syndrome: 1. Insulin resistance (HOMA-IR ≥ 1.7 or fasting glucose ≥ 100 mg/dl) 2. Triglyceride concentration ≥ 150 mg/dl 3. HDL-cholesterol \< 40 mg/dl for women/ \< 50 mg/dl for men 4. Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg * knowledge of English Exclusion Criteria: * gastrointestinal disorders such as IBD, IBS, celiac disease, chronic constipation, chronic diarrhoea * history of abdominal surgery, except for appendectomy * Use of antihypertensive, cholesterol lowering, glucose-regulating drugs and corticosteroids * Use of antibiotics 3 months prior to the start or during the study * Use of probiotics and prebiotics 2 weeks prior to the start of the study/ during the study * Being on weight loss, gluten-free, lactose-free or vegan diet * Pregnancy, lactation or wish