NCT06432517 Sources and Mechanisms of Energy Compensation
| NCT ID | NCT06432517 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences |
| Condition | Energy Expenditure |
| Study Type | INTERVENTIONAL |
| Enrollment | 81 participants |
| Start Date | 2024-05-20 |
| Primary Completion | 2025-09-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 81 participants in total. It began in 2024-05-20 with a primary completion date of 2025-09-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Excess energy, obesity and obesity-related diseases are important global health issues. Although it is known that obesity is an issue of energy balance, the components of energy expenditure seem to be inter-related in complex non-additive ways. The aim of this study is to explore the downstream impacts of exercise on short term changes in both expenditure and energy intake. The primary question the investigators are asking is whether moderate to high intensity exercise influences the basal energy expenditure and/or energy intake/macronutrient preference in young adult males? (A similar study will be performed on females in a different registration). The investigators will use a specially designed feeding table to measure energy intake and macronutrient intake, which is easy to quantify intake compensation. Basal metabolism will be measured by hood indirect calorimetry. The investigators will explore the factors that influence the level of compensation in expenditure and intake, in particular body composition. Participants will be asked to come to the lab after 10 hours fast for body composition tests including Dual Energy X-ray Absorptiometry(DXA), Magnetic Resonance Image(MRI) and Bioelectrical Impedance Analysis(BIA). They will then be asked (not) to do 30 minutes of moderate-to-vigorous exercise after an energy-limiting breakfast, during which metabolic rate levels and changes in dietary composition will be recorded by gas exchange and standardized buffet. In addition, participants' subjective hunger and preferences will also be recorded by questionnaires. Venous blood will be collected to measure metabolic and hormone factors, blood glucose will be measured by Continuous Blood Glucose Monitor (CGM).
Eligibility Criteria
Inclusion Criteria: * Healthy adults (men) * 18-40 years old * BMI (body mass index)≥18.5 kg/m2 Exclusion Criteria: * Those who have undergone surgery in the past 6 months. * People are requiring long-term medication. * People have metabolic diseases, like diabetes, hypoglycemia, gout, osteoporosis, et al. * People have digestive diseases, like gastric ulcer, pancreatitis, Intestinal obstruction, et al. * People have sports injury, like fracture, Joint injury, et al. * Those who have recently lost weight for various medical reasons (e.g. cancer, etc.). * People are losing weight by tablets. * People are suffering from infectious diseases (e.g. HIV, etc.) * People have blood phobia, pathological hypo or hyper tension. * People with impaired glucose tolerance. * Those who are afflicted with claustrophobia.
Contact & Investigator
John Speakman
STUDY CHAIR
Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Frequently Asked Questions
Who can join the NCT06432517 clinical trial?
This trial is open to male participants only, aged 18 Years or older, up to 40 Years, studying Energy Expenditure. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06432517 currently recruiting?
Yes, NCT06432517 is actively recruiting participants. Contact the research team at j.speakman@abdn.ac.uk for enrollment information.
Where is the NCT06432517 trial being conducted?
This trial is being conducted at Shenzhen, China.
Who is sponsoring the NCT06432517 clinical trial?
NCT06432517 is sponsored by Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences. The principal investigator is John Speakman at Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences. The trial plans to enroll 81 participants.