NCT06692400 The Effects of Endotracheal Suctioning on Pain and Serum Markers
| NCT ID | NCT06692400 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Loma Linda University |
| Condition | Intensive Care Unit ICU |
| Study Type | INTERVENTIONAL |
| Enrollment | 110 participants |
| Start Date | 2025-01-30 |
| Primary Completion | 2026-04 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 110 participants in total. It began in 2025-01-30 with a primary completion date of 2026-04.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be uncomfortable and cause stress. The main questions this study aims to answer are: Does ETT suctioning raise pain levels as measured by the Critical-Care Pain Observation Tool (CPOT)? Does ETT suctioning increase certain chemicals in the blood (hypoxanthine, xanthine, and uric acid) that show stress and lack of oxygen in the body? Researchers will compare patients who have ETT suctioning (intervention group) with those who do not have suctioning during the study period (control group) to see if there are differences in pain and blood markers of stress. Participants will: Have pain measured before and after suctioning using the CPOT. Have blood samples taken from an existing line at three time points: 5 minutes before, 5 minutes after, and 30 minutes after suctioning. Provide demographic information (like age, gender, and diagnosis) from medical records. This research will help improve how pain is managed for ICU patients who cannot speak for themselves, potentially leading to better pain relief methods in the future.
Eligibility Criteria
Inclusion Criteria: * Adults (aged 18 years and older) * Current diagnosis of flu, pneumonia, COVID, or sepsis * Intubated and receiving mechanical ventilation. * Have arterial lines placed * Require endotracheal suctioning as part of their care Exclusion Criteria: * Patients receiving neuromuscular blocking agents * Contraindications for blood draws (hemoglobin levels below 8.0 g/dL; Jehovah's Witness)
Contact & Investigator
Elizabeth Johnston Taylor, PhD, FAAN
PRINCIPAL INVESTIGATOR
Loma Linda University School of Nursing
Frequently Asked Questions
Who can join the NCT06692400 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Intensive Care Unit ICU. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06692400 currently recruiting?
Yes, NCT06692400 is actively recruiting participants. Contact the research team at bmcarr@llu.edu for enrollment information.
Where is the NCT06692400 trial being conducted?
This trial is being conducted at Loma Linda, United States.
Who is sponsoring the NCT06692400 clinical trial?
NCT06692400 is sponsored by Loma Linda University. The principal investigator is Elizabeth Johnston Taylor, PhD, FAAN at Loma Linda University School of Nursing. The trial plans to enroll 110 participants.