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Recruiting Phase 4 NCT04192656

The Effect of PAP on ISSHL Comorbided With OSA

Trial Parameters

Condition Sudden Hearing Loss
Sponsor Beijing Tsinghua Chang Gung Hospital
Study Type INTERVENTIONAL
Phase Phase 4
Enrollment 102
Sex ALL
Min Age 18 Years
Max Age 70 Years
Start Date 2019-11-01
Completion 2024-12
Interventions
non-invasive positive airway pressureMethylprednisolone HemisuccinateGinaton

Brief Summary

This clinical randomized controlled study is to explore the effect of positive airway pressure(PAP) on patients in Beijing Tsinghua Changgung Hospital diagnosed with both idiopathic sudden sensorineural hearing loss comorbided(ISSHL) and obstructive sleep apnea(OSA) between Dec. 2019 to Dec. 2029.

Eligibility Criteria

Inclusion Criteria: 1. aged \>= 18 and \<= 70, 2. diagnosed with OSA by full-night in-lab or home-stay PSG according to AASM 2012 criteria, and AHI \> 15/h, 3. diagnosed with ISSHL by AAO-HNS 2019 criteria, 4. ISSHL onset within 1 week. Exclusion Criteria: 1. sudden hearing loss with certain causes, 2. with severe comorbid diseases, 3. pregnant or breast-feeding women, 4. AHI \<= 15/h, 5. hearing threshold recovered \> 50% when included, 6. previously regularly treated with PAP.

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