NCT06722937 The Collagen Factors of Rapid Progression of Keratoconus in Children.
| NCT ID | NCT06722937 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Zhongshan Ophthalmic Center, Sun Yat-sen University |
| Condition | Keratoconus |
| Study Type | OBSERVATIONAL |
| Enrollment | 160 participants |
| Start Date | 2023-04-14 |
| Primary Completion | 2025-04-13 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 160 participants in total. It began in 2023-04-14 with a primary completion date of 2025-04-13.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this observational study was to understand the differences in clinical features and mechanisms of keratoconus between children and adults. The main questions it aimed to answer as follows: (1) to understand the characteristics of keratoconus in Chinese children. (2) to observe corneal stromal cells at the cytological level using in vivo corneal laser confocal microscopy and explore the pathogenesis.
Eligibility Criteria
Inclusion Criteria: * ① Patients with keratoconus who visit the refractive clinic. 1. The height of the posterior corneal surface is greater than 16 microns under the Pentacam corneal topography. 2. ARTAve \< 424 microns, ARTMax \< 339 microns. 3. Clinical non-inflammatory or traumatic corneal thinning and corneal astigmatism. * Aged between 10 and 50 years old, no gender restrictions. * Agree to accept and complete follow-up examinations on time. ④ I and my guardian understand and agree to participate in this clinical trial and sign the informed consent form. Exclusion Criteria: * ① There is a history of contact lens wearing in the last four weeks. * poor fixation and can not cooperate with the examination. ③ History of eye trauma and surgery (including corneal collagen cross-linking surgery). * History of other related eye diseases: corneal disease, glaucoma, retinal choroid disease, etc.. ⑤ severe eye diseases affecting imaging such as dry eye, conjunctivitis and pterygium. ⑥ Any systemic disease affecting eye morphology and refractive interstitium.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06722937 clinical trial?
This trial is open to participants of all sexes, aged 10 Years or older, up to 50 Years, studying Keratoconus. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06722937 currently recruiting?
Yes, NCT06722937 is actively recruiting participants. Contact the research team at canotoday@foxmail.com for enrollment information.
Where is the NCT06722937 trial being conducted?
This trial is being conducted at Guangzhou, China.
Who is sponsoring the NCT06722937 clinical trial?
NCT06722937 is sponsored by Zhongshan Ophthalmic Center, Sun Yat-sen University. The trial plans to enroll 160 participants.