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Recruiting Phase 1 NCT05883241

Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Pain Related to Bone Fracture

Trial Parameters

Condition Bone Fracture
Sponsor ZetrOZ, Inc.
Study Type INTERVENTIONAL
Phase Phase 1
Enrollment 90
Sex ALL
Min Age 18 Years
Max Age 80 Years
Start Date 2023-06-01
Completion 2026-02-01
Interventions
Sustained Acoustic Device with 2.5% Diclofenac Patch2.5% Diclofenac Patches

Brief Summary

The purpose of this study is to assess the ability of long-duration low-intensity therapeutic ultrasound (LITUS) to alleviate bone-fracture related pain over a 12-week period. The primary objective of this study is to evaluate the analgesic effect of LITUS in subjects suffering from bone-fracture pain. Secondary objectives are to assess the ability of LITUS to improve patients return to work time.

Eligibility Criteria

Inclusion Criteria: * Have physician-diagnosed bone fracture * Are between 18-80 years of age * Report a pain score between 3-7 (range: 0-10) prior to enrolment * Report that pain from fracture negatively affects quality of life * Are willing not to use any cream, gel, or topical solution during the administration of treatment other than the approved treatment provided to the subject at the initiation of the study * Are deemed appropriate by their physician or by the study site physician to participate. * Be willing and able to self-administer treatment daily within their place of residence or during normal daily activity, excluding bathing, showering, or other water activities which may result in submersion of the study device. * Not use or initiate opioid and/or non-opioid analgesic medications. * Be willing to discontinue any other interventional treatment modalities on the affected area during the study period (e.g., transcutaneous electrical nerve stimulation, electronic muscle st

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