The Impact of Glomerular Disorders on Bone Quality and Strength
Trial Parameters
Brief Summary
The primary objectives of this study are to: (1) determine the impact of glomerular disease on bone strength and (2) investigate the pathophysiologic underpinnings of impaired bone strength in glomerular disease.
Eligibility Criteria
Inclusion Criteria for participants with glomerular disease: 1. CureGN participant or CureGN Eligible CureGN eligible is defined as having a diagnosis of Glomerulonephropathy (GN). Patients would otherwise be enrolled in be in CureGN study, except for lacking a minor entry criteria, such as: 1. First diagnostic kidney biopsy within 5 years of CureGN study enrollment 2. Access to first kidney biopsy report and/or slides or not being interested in study participation. 2. Males or females 5 to 55 years (premenopausal for women) 3. Females must have a negative urine/serum pregnancy test 4. Stable doses of nutritional vitamin D or active vitamin D therapy for at least 3 months before enrollment ((if on either form of Vitamin D) 5. Consent/Parental/guardian permission (informed consent) and if appropriate, child assent Exclusion Criteria for all participants 1. Chronic Dialysis 2. Solid organ transplantation 3. Lower extremity amputations or non-ambulatory 4. Malignancy requiring chemotherap