NCT07247968 Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study
| NCT ID | NCT07247968 |
| Status | Recruiting |
| Phase | EARLY_Phase 1 |
| Sponsor | Min Su |
| Condition | Esketamine |
| Study Type | INTERVENTIONAL |
| Enrollment | 220 participants |
| Start Date | 2025-11-25 |
| Primary Completion | 2026-11-20 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 220 participants in total. It began in 2025-11-25 with a primary completion date of 2026-11-20.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The study design was a randomized, double blind, parallel controlled trial.The goal of this clinical trial is to learn if esketamine-assisted modified electroconvulsive therapy (ESK-MECT) works to treat severe depression in adolescents. It will also learn about the safety of ESK-MECT. The sample size was calculated based on the response rate of patients with depression undergoing electroconvulsive therapy(ECT).According to the results of the pilot study,the efficacy rate of subjects receiving adjunctive esketamine was approximately 78%,while the efficacy rate of those receiving only propofol was 63%.The expected superiority difference in remission rates between the two groups was 15%(one-sided)for the power calculation.Assuming a significance level of α=0.05 and a test power of β=0.2,with a 1:1 ratio of sample sizes between the two groups,the total sample size was calculated to be 198 using the PASS software(PASS 2023).Considering a dropout rate of 10%,a total of 220 subjects were required,with 110 subjects in each group. 1. experimental group The patients were given intravenous injection of 0.25 mg / kg esketamine, 1.5 mg / kg propofol and 1 mg / kg succinylcholine in turn. After anesthesia, the patients were given electroconvulsive therapy. 2. In the control group The patients were given normal saline consistent with esketamine injection volume, 1.5mg/kg of propofol and 1mg / kg of succinylcholine. After anesthesia, the patients were given electroconvulsive therapy. Efficacy evaluation 1. Main efficacy indicators Response rate of depressive symptoms after MECT treatment Response is defined as two consecutive HAMD-24 scores ≤ 50% before treatment after receiving MECT treatment. The response rate is calculated as the number of patients who achieved as response divided by the total number of patients receiving MECT.In this study, the 24-item version of HAMD was utilized. Participants will: Be randomly assigned to the esketamine group or the control group, and receive standard MECT treatment. Have seizure parameters, seizure duration, vital signs, and complications recorded. Complete psychiatric scale assessments, including HAMD-24, BSS, PANSS, WMS-RC and MoCA. Be assessed at the following time points: HAMD-24 and BSS after each treatment; PANSS after each treatment course;WMS-RC and MoCA before MECT and after one treatment course. All subjects did not discontinue antidepressants before modified electroconvulsive therapy(MECT),and they were fasting for 8 hours and no fluids for 2 hours.Three minutes before MECT,continuous qCON monitoring(Apollo-9000A,Chongqing Xideer Medical Equipment Co.,Ltd.,China)was initiated,while monitoring blood pressure,heart rate,and peripheral capillary oxygen saturation.Preoxygenation was administered for 3 minutes.The qCON monitor uses three electrodes on the forehead to collect raw electroencephalogram(EEG)signals.The qCON monitoring includes the qCON index,qNOX index,burst suppression(BS),and signal quality index(SQI).
Eligibility Criteria
Inclusion Criteria: * Inpatients diagnosed with Major Depressive Disorder according to the International Classification of Diseases,11th Revision(ICD-11),and scheduled for Modified Electroconvulsive Therapy(MECT); * Aged 13 to 17 years,regardless of gender; * Educational attainment of primary school or higher; * Normal hearing and vision,including color perception; * Voluntary participation in the study with signed informed consent; * American Society of Anesthesiologists(ASA)physical status classification I-II. Exclusion Criteria: * Severe cardiovascular disease,significant arrhythmias,or other cardiac conditions; * Inability to complete the assessment scales; * History of substance abuse; * Received electroconvulsive therapy(ECT)within 6 months prior to the study; * Severe cerebrovascular disease,severe hypertension,intracranial hypertension,or presence of intracranial electrodes; * Severe allergy or contraindication to propofol or succinylcholine; * Comorbid with other psychiatric disorders.
Contact & Investigator
Su Min
PRINCIPAL INVESTIGATOR
First Affiliated Hospital of Chongqing Medical University
Frequently Asked Questions
Who can join the NCT07247968 clinical trial?
This trial is open to participants of all sexes, aged 13 Years or older, up to 17 Years, studying Esketamine. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT07247968 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT07247968 currently recruiting?
Yes, NCT07247968 is actively recruiting participants. Contact the research team at 3164233689@qq.com for enrollment information.
Where is the NCT07247968 trial being conducted?
This trial is being conducted at Chongqing, China, Chongqing, China.
Who is sponsoring the NCT07247968 clinical trial?
NCT07247968 is sponsored by Min Su. The principal investigator is Su Min at First Affiliated Hospital of Chongqing Medical University. The trial plans to enroll 220 participants.