NCT05525845 Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
| NCT ID | NCT05525845 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Mayo Clinic |
| Condition | Healthy |
| Study Type | INTERVENTIONAL |
| Enrollment | 15 participants |
| Start Date | 2022-09-08 |
| Primary Completion | 2028-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 15 participants in total. It began in 2022-09-08 with a primary completion date of 2028-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.
Eligibility Criteria
Inclusion Criteria: * BMI 18-25 kg/m\^2. * Weight stable for 3 months prior to study entry. * For females: study days will be scheduled during the follicular phase of their menstrual cycle (i.e., the first 13 days (about 2 weeks) of the cycle). * Able to provide written informed consent prior to any study procedures and be willing and able to follow study procedures.. * Ability to perform light to moderate physical activity. Exclusion Criteria: * Any contraindication for MRI scanning. * Any history of childhood (\> 95th percentile) or adult obesity (BMI \>30 kg/m\^2). * Claustrophobia. * High intensity training or physical activity. * Any contraindication for intragastric balloon insertion. * Any allergies to the study meals. * Any history of eating disorder. * Any substance abuse disorder (including alcohol and tobacco). * Any history of psychiatric disorders. * Any cardiovascular, endocrine, pulmonary, neurological, or gastrointestinal comorbidities. * Pregnancy or nursing. * Any history of bariatric surgery or endoscopic bariatric procedure. * Use of any medication or supplement that alters appetite. * Patient has a known history of any condition or factor judged by the investigator to prevent participation in the study or which might hinder study adherence.
Contact & Investigator
Andres Acosta, MD, PhD
PRINCIPAL INVESTIGATOR
Mayo Clinic
Frequently Asked Questions
Who can join the NCT05525845 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, up to 50 Years, studying Healthy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05525845 currently recruiting?
Yes, NCT05525845 is actively recruiting participants. Contact the research team at RSTINDIVOBESITY@mayo.edu for enrollment information.
Where is the NCT05525845 trial being conducted?
This trial is being conducted at Rochester, United States.
Who is sponsoring the NCT05525845 clinical trial?
NCT05525845 is sponsored by Mayo Clinic. The principal investigator is Andres Acosta, MD, PhD at Mayo Clinic. The trial plans to enroll 15 participants.