NCT06663631 Study on Hibernation-like Therapy Based on Mechanical Thrombectomy
| NCT ID | NCT06663631 |
| Status | Recruiting |
| Phase | Phase 1 |
| Sponsor | Capital Medical University |
| Condition | Acute Ischemic Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 32 participants |
| Start Date | 2024-11-09 |
| Primary Completion | 2025-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 32 participants in total. It began in 2024-11-09 with a primary completion date of 2025-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to learn whether chlorpromazine and promethazine（C+P）is safe in Acute Ischemic Stroke（AIS) patients and determine the maximum dosage. It will also evaluate the preliminary efficacy of C+P in AIS. The main questions it aims to answer are: What is the optimal dosage of C+P that is safe without causing adverse effects in AIS patients? What is the optimal dosage of C+P that potentially works to treat AIS? Researchers will compare C+P with placebo (saline solution without C+P) to see if C+P is safe and effective in treating Acute Ischemic Stroke. Participants will: Receive C+P or placebo at the same time as endovascular thrombectomy begins. Patients will be observed for 72 hours to see if there were any adverse effects related to C+P. Infarct volumes will be evaluated using Computed Tomography. Functional outcomes will be assessed at 90 days.
Eligibility Criteria
Inclusion Criteria: * Clinical Inclusion Criteria: 1. Age between 18-80 years(including the critical value) 2. Ischemic stroke with a National Institutes of Health Stroke Scale (NIHSS) score ranging from 6-20 3. Time from last known to be well to randomization within 24h 4. Pre-stroke Modified Rankin Scale scoring 0-1. 5. With indications of reperfusion therapy (including intravenous thrombolysis and endovascular thrombectomy). 6. Informed consent signed by patients or their legal relatives. 7. CT angiography (CTA) confirmed large vessel occlusion of anterior circulation 8. Alberta Stroke Program Early Computed Tomography Score (ASPECT) score of 6-10. 9. initial infarct volume on CT perfusion (CTP) lesser than 70ml; a ratio of hypoperfused volume to infarcted volume greater than 1.8; absolute mismatch volume greater than 15 ml according to DEFUSE-3 trial. Exclusion Criteria: * Clinical Exclusion Criteria: 1. Clinical findings suggest intracranial parenchymal hemorrhage or subarachnoid hemorrhage. 2. Accompanied by epilepsy. 3. Accompanied by coma or mental disorders, may interfere with neurological function assessment. 4. History of premorbid phenothiazine allergy or contraindication. 5. History of allergy to iodine contrast medium or anaphylactic shock 6. Baseline blood glucose \<50mg/dL (2.78mmol) or \>400mg/dL (22.20mmol) \* Acceptable fingertip blood glucose results 7. Baseline platelet \<50×109 /L 8. Recent (i.e. within 30 days prior to randomization) history of gastrointestinal or other clinically significant bleeding; Active bleeding, abnormal clotting factors, or bleeding tendency (INR≥3 or PT≥3×ULN on anticoagulants; If the investigator believes that the subject does not have coagulation dysfunction, it is not necessary to wait for the results of the coagulation test before deciding whether to enroll.) 9. The stroke is accompanied by fever, or there is an active infection requiring systemic treatment (such as active tuberculosis, etc.) 10. Expected survival less than 90 days (According to the Chinese Guidelines for Early Endovascular Interventional Diagnosis and Treatment of Acute Ischemic Stroke 2022, expected survival less than 90 days is a contraindication for endovascular therapy) 11. A history of severe cardiovascular disease, including but not limited to: uncontrolled hypertension (systolic blood pressure \>180 mmHg or diastolic blood pressure \>105 mmHg after standard treatment), hypotension (systolic blood pressure ≤100 mmHg after standard treatment), or pulmonary hypertension; Had unstable angina pectoris, myocardial infarction, or bypass or stent surgery within 6 months before randomization; New York Heart Association (NYHA) grade 3-4 history of chronic heart failure; Clinically significant valvular disease; Severe arrhythmias requiring treatment (except atrial fibrillation and paroxysmal supraventricular tachycardia), including QT interval ≥450ms for men and ≥470ms for women 12. accompanied by chronic obstructive pulmonary disease（COPD）, tuberculosis, pneumonia, pneumothorax, atelectasis, pulmonary fibrosis, bronchopulmonary dysplasia, pleural effusion, acute respiratory distress syndrome, respiratory irregularity and other lung diseases 13. Severe hepatic and renal insufficiency, including but not limited to: cirrhosis, hepatic encephalopathy, ascites, renal failure or uremia (Ccr\<25ml/min), hepatorenal syndrome, etc 14. Pregnancy or lactating women 15. Participation in other clinical trials and have used an investigational drug or medical device 16. Patients that may not be able to complete the study for other reasons or who the investigator believes should not be included * Image exclusion criteria: 1. computed tomographic angiography（CTA）/magnetic resonance angiography（MRA）/digital substraction angiography（DSA） shows excessive vascular curvature, which may hinder delivery of interventional devices 2. Cerebrovascular inflammation is suspected based on medical history and CTA/MRA/DSA 3. Aortic dissection is suspected based on medical history and CTA/MRA/DSA 4. CTA/MRA/DSA confirmed multi-vascular regional occlusion (such as bilateral anterior circulation or anterior/posterior circulation, extracranial carotid artery with intracranial tandem lesions), or clinical evidence of bilateral or multi-regional infarction 5. CTA/MRA/DSA confirms moyamoya disease or moyamoya syndrome 6. CT/MRI confirmed a significant midline shift effect 7. CT/MRI confirms the presence of intracranial tumors (except cerebellar meningioma) CT/MRI confirmed intracranial hemorrhage
Contact & Investigator
Xunming Ji, Doctor
STUDY CHAIR
Capital Medical University
Frequently Asked Questions
Who can join the NCT06663631 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Acute Ischemic Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06663631 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT06663631 currently recruiting?
Yes, NCT06663631 is actively recruiting participants. Contact the research team at Jixm@ccmu.edu.cn for enrollment information.
Where is the NCT06663631 trial being conducted?
This trial is being conducted at Linyi, China.
Who is sponsoring the NCT06663631 clinical trial?
NCT06663631 is sponsored by Capital Medical University. The principal investigator is Xunming Ji, Doctor at Capital Medical University. The trial plans to enroll 32 participants.
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