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Recruiting Phase 1 NCT07093580

Study of S-892216 Long-acting Injectable (LAI) in Healthy Adult Participants

Trial Parameters

Condition Healthy Participants
Sponsor Shionogi
Study Type INTERVENTIONAL
Phase Phase 1
Enrollment 98
Sex MALE
Min Age 18 Years
Max Age 55 Years
Start Date 2025-07-29
Completion 2027-05-26
Interventions
S-892216-LAIPlacebo

Brief Summary

The purpose of this study is to investigate the safety, tolerability, and pharmacokinetics (PK) of single- and multiple-dose administration of S-892216-LAI in healthy adults.

Eligibility Criteria

Key Inclusion Criteria: * Body mass index (BMI) ≥18.5 and ≤32.0 kilograms (kg)/square meter (m\^2) Key Exclusion Criteria: * Presence or history of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrinological, hematological, neurological, or ophthalmological (for example, increased intra-ocular pressure) disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; constituting a risk when taking the study intervention; or interfering with the interpretation of data per the investigator's assessment. * History of cancer except for basal cell or squamous epithelial carcinomas of the skin that have been resected with no evidence of metastatic disease for 3 years. * Require medication or other treatment (for example, dietary restrictions or physical therapy). * Participated in any other clinical study involving an investigational study intervention or any other type of medical research within 30 days, or 5 times the half-life of the in

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