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healthy participants

Total Trials

19

Recruiting Now

19

Trial Phases

Phase 1

Clinical trials often recruit healthy volunteers for Phase 1 pharmacokinetic and safety studies, vaccine immunogenicity assessments, and normal physiological reference studies. These trials are essential for establishing safe dose ranges and understanding how drugs behave in the absence of disease before testing in patient populations.

Healthy volunteer studies include first-in-human drug trials, vaccine efficacy (flu, RSV, COVID-19, malaria), microbiome intervention studies, exercise physiology research, and device safety assessments. Compensation is often provided; eligibility typically requires no significant medical history and a negative drug screen.

Healthy volunteer trials require participants to be in good general health with no significant medications. Many exclude smokers, pregnant individuals, and those with recent prior trial participation.

Frequently Asked Questions — healthy participants Clinical Trials

How many clinical trials are currently recruiting for healthy participants?

ClinicalMetric currently tracks 19 actively recruiting clinical trials for healthy participants, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 19. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for healthy participants?

healthy participants research spans Phase 1 (11 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a healthy participants clinical trial?

Eligibility criteria for healthy participants trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

11

Top Sponsors

AstraZeneca 2 trials

Bristol-Myers Squibb 2 trials

University of Wisconsin, Madison 2 trials

Debiopharm International SA 1 trial

Bionyra Pharma 1 trial

Recruiting Clinical Trials

NCT07511205 Phase 1

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.

United States, Unite...

NCT07035769 Phase 1

A First-in-Human Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Multiple Oral Doses of Debio 1453P in Healthy Adults

Debiopharm International SA

NCT07746817 Phase 1

A Study of BYN-001 in Healthy Adults and in Adults With Moderate to Severe Atopic Dermatitis

Feasibility Study Aiming at Pre-Analytical Standardization of Whole Blood Processing for Liquid Biopsy Applications

NCT06975124 Phase 1

taVNS Effects on Fear Ratings in Naturalistic Context

University of Electronic Scien...

NCT07783503 Phase 1

A Drug-drug Interaction Study to Assess the Effect of Phenytoin and Itraconazole on the Pharmacokinetics of Pelabresib in Healthy Participants

Novartis Pharmaceuticals

Monitoring Changes in Blood Circulating Metabolites Using Minimally Invasive Techniques

Örebro University, Sweden

NCT07780383 Phase 1

A Study to Evaluate the Drug Levels, Absolute Bioavailability, Safety, Tolerability, and Immunogenicity of Single-Dose of BMS-986446 in Healthy Adults After Single-dose Administration, and Participants With Early Alzheimer's Disease After Multiple Dose Administration

Bristol-Myers Squibb

NCT07290283 Phase 1

A Study to Investigate Safety, Tolerability, and Pharmacokinetics of AZD3974 in Healthy Participants

NCT07093580 Phase 1

Study of S-892216 Long-acting Injectable (LAI) in Healthy Adult Participants

Global Reference Ranges - Singapore

Combined Regulatory Effects of 40 Hz eTNS and Multisensory Stimulation on Brain Networks

Xidian University

NCT07171034 Phase 1

A Phase I Study of KLA318-2 Nanocrystal Injection

Hunan Kelun Pharmaceutical Co....

CanCan Body Composition Study

Pennington Biomedical Research...

Pupillary Dilation Reflex in Healthy Volunteers

Children's National Research I...

NCT07544628 Phase 1

A Phase 1 Study of Navlimetostat Tablet Formulations

Bristol-Myers Squibb

NCT07219719 Phase 1

Temporal Interference for Thalamocortical Activity and Network Modulation

University of Wisconsin, Madis...

Non-invasive Ultrasonic Auricular Vagus Nerve Stimulation

University of Nottingham

Biomarkers Study in Infants With Prior Neonatal Brain Injury

University of Wisconsin, Madis...

Related Conditions

obesity (1) atopic dermatitis (1) alzheimer s disease (1) young healthy adults (1) elderly people aged 65 or more (1) hie hypoxic ischemic encephalopathy (1) perinatal anoxic ischemic brain injury (1) premature birth (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology