Medical Condition

healthy participants

Total Trials

14

Recruiting Now

14

Trial Phases

Phase 1

Clinical trials often recruit healthy volunteers for Phase 1 pharmacokinetic and safety studies, vaccine immunogenicity assessments, and normal physiological reference studies. These trials are essential for establishing safe dose ranges and understanding how drugs behave in the absence of disease before testing in patient populations.

Healthy volunteer studies include first-in-human drug trials, vaccine efficacy (flu, RSV, COVID-19, malaria), microbiome intervention studies, exercise physiology research, and device safety assessments. Compensation is often provided; eligibility typically requires no significant medical history and a negative drug screen.

Healthy volunteer trials require participants to be in good general health with no significant medications. Many exclude smokers, pregnant individuals, and those with recent prior trial participation.

Frequently Asked Questions — healthy participants Clinical Trials

How many clinical trials are currently recruiting for healthy participants?

ClinicalMetric currently tracks 14 actively recruiting clinical trials for healthy participants, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 14. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for healthy participants?

healthy participants research spans Phase 1 (7 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a healthy participants clinical trial?

Eligibility criteria for healthy participants trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Top Sponsors

AstraZeneca 2 trials

Ball State University 1 trial

Chang Gon Kim 1 trial

University of Nottingham 1 trial

Sichuan Kelun Pharmaceutical Research Institute Co., Ltd. 1 trial

Recruiting Clinical Trials

NCT06980428 Phase 1

Recruiting

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4954 in Healthy Adult Participants With or Without Elevated Lipoprotein (a) (Lp[a]) Levels, and Participants With Dyslipidemia

Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.

Ball State University

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NCT07598747

Recruiting

Prospective Study for the Development, Validation and Confirmation of a Multi-Cancer Early Detection Platform Through Whole-Genome Sequencing Analysis of Circulating DNA in Cancer and Non-Cancer Subjects

Non-invasive Ultrasonic Auricular Vagus Nerve Stimulation

University of Nottingham

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NCT07030790 Phase 1

Recruiting

A Phase I Clinical Study of a Single Dose of KLA480

Sichuan Kelun Pharmaceutical R...

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NCT07083089

Recruiting

Early Stage of Alzheimer's and Parkinson's Diseases, HearIng Relevance (SAPHIR)

Location- and Frequency-Dependent Effects of Thalamic Temporal Interference Stimulation During Sleep

University of Wisconsin, Madis...

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NCT07539090 Phase 1

Recruiting

Evaluate the Effect of Vimseltinib on Pharmacokinetics of Combined Oral Contraceptive (Ethinyl Estradiol/Levonorgestrel)

Deciphera Pharmaceuticals, LLC

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NCT07463196 Phase 1

Recruiting

A Study Investigating the Safety, Absorption, Elimination, and the Effect on the Immune System of ACI-19764 in Healthy Participants and in Participants With Cardiovascular Risk Factors

A First-In-Human Study of ARO-033 in Adult Participants

Arrowhead Pharmaceuticals

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NCT07668167

Recruiting

Combined Regulatory Effects of 40 Hz eTNS and Multisensory Stimulation on Brain Networks

Learning Cardiopulmonary Resuscitation in the School Setting: RCP-KNOW Project.

University of Castilla-La Manc...

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NCT07511205 Phase 1

Recruiting

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.

Enrollment

104 pts

Location

United States, Unite...

Assess the Safety, Tolerability, and Pharmacokinetics of HL-1186 in Healthy Participants

Shanghai Yidian Pharmaceutical...

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Related Conditions

obesity (2) dyslipidemia (1) cancer (1) mild cognitive impairment mci amnestic (1) parkinson disease pd (1) healthy adult participants (1) type 2 diabetes mellitus t2dm (1) knowledge acquisition (1) cardiopulmonary resuscitation cpr (1) children (1) school (1)

ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: September 2026 · Data Methodology