NCT07650188 Stimulating the Aging Brain Using Brain and Sensory Stimulation
| NCT ID | NCT07650188 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Medical College of Wisconsin |
| Condition | Primary Progressive Aphasia |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2026-06-01 |
| Primary Completion | 2031-05-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2026-06-01 with a primary completion date of 2031-05-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this project is to investigate whether transcranial electrical stimulation and sensory stimulation affect language outcomes in individuals with primary progressive aphasia (PPA). The main questions it aims to answer are: Does transcranial alternating current stimulation (tACS) affect verbal short-term memory (STM) in individuals with PPA? Does a single session of multisensory stimulation affect verbal STM in individuals with PPA? Researchers will compare active tACS to sham tACS (a fake stimulation condition) to see if active tACS improves verbal STM. Researchers will compare pre-multisensory stimulation to post-stimulation performance to see if multisensory stimulation improves verbal STM. Participants will: Undergo EEG, MRI (anatomical and functional) May complete a cognitive exam Undergo tACS over 3 separate sessions Undergo multisensory stimulation Complete language tasks before, during and/or after stimulation
Eligibility Criteria
Inclusion Criteria: * Clinical exam supports diagnosis of PPA and/or MCI with no report of difficulty functioning in basic or instrumental activities of daily living. * Completed clinical cognitive exam within 6 months of study baseline visit OR neuropsychological research battery within 6 months of study baseline visit. Exclusion Criteria: * Evidence of dementia at baseline * Known history of neoplasm, symptomatic stroke, moderate to severe traumatic brain injury, or other significant neurologic event * Age \<45 years. * Evidence of severe psychiatric illness (e.g., bipolar disorder, schizophrenia). * Presence of cardiac stimulators or pacemakers * Any other implants near the scalp or in the eye * Contraindications to MRI or stimulation * Pregnancy * History of ongoing or unmanaged seizures * History of dyslexia or other developmental learning disabilities
Contact & Investigator
Priyanka Shah-Basak, PhD
PRINCIPAL INVESTIGATOR
Medical College of Wisconsin
Frequently Asked Questions
Who can join the NCT07650188 clinical trial?
This trial is open to participants of all sexes, aged 45 Years or older, studying Primary Progressive Aphasia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07650188 currently recruiting?
Yes, NCT07650188 is actively recruiting participants. Contact the research team at sschoenrock@mcw.edu for enrollment information.
Where is the NCT07650188 trial being conducted?
This trial is being conducted at Milwaukee, United States.
Who is sponsoring the NCT07650188 clinical trial?
NCT07650188 is sponsored by Medical College of Wisconsin. The principal investigator is Priyanka Shah-Basak, PhD at Medical College of Wisconsin. The trial plans to enroll 20 participants.