Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting
This study tests whether doctors can use frozen testicular tissue that was saved before cancer treatment to restore fertility in men. The procedure involves transplanting spermatogonial stem cells (the cells that produce sperm) back into the testicles using ultrasound guidance, or grafting testicular tissue directly.
Key Objective:This trial is testing whether stem cell transplantation and tissue grafting can help men regain the ability to produce sperm and father biological children after gonadotoxic therapy.
Who to Consider:Men who banked testicular tissue before undergoing cancer treatment or other gonadotoxic therapy and wish to explore options for restoring fertility should consider enrolling.
Trial Parameters
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Brief Summary
Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.
Eligibility Criteria
Inclusion Criteria: * Male participant at least in Tanner stage 3 * Previously cryopreserved and stored testicular tissue/cells (frozen due to an infertility-risking diagnosis or treatment such as chemotherapy or radiation) available for autologous transplantation and grafting * Healthy enough to undergo anesthesia * Written clearance for the procedure from the patient's hematologist or oncologist to confirm the patient has finished treatment for primary condition and are clear to undergo autologous stem cell transplant Exclusion Criteria: * Participants considered to be high risk for surgical complications * Participants with a history of leukemia, lymphoma or testicular cancer or a cancer that likely involved testicles at the time of testicular tissue collection * Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.