NCT06491823 Speech Motor Learning and Retention (Aim 2)
| NCT ID | NCT06491823 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Yale University |
| Condition | Speech |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2024-10-01 |
| Primary Completion | 2028-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 120 participants in total. It began in 2024-10-01 with a primary completion date of 2028-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.
Eligibility Criteria
Inclusion Criteria: * Fluent English speakers * Right-handed * Normal hearing * No speech disorder or reading disability Exclusion Criteria: * Cardiac pacemaker * Aneurysm clip * Heart or Vascular clip * Prosthetic valve * Metal implants * Metal in brain, skull, or spinal cord * Implanted neurostimulator * Medication infusion device * Cochlear implant or tinnitus (ringing in ears) * Personal and/or family history of epilepsy or other neurological disorders or history of head concussion * Psychoactive medications * Pregnancy
Contact & Investigator
David Ostry
PRINCIPAL INVESTIGATOR
Yale University
Frequently Asked Questions
Who can join the NCT06491823 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 40 Years, studying Speech. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06491823 currently recruiting?
Yes, NCT06491823 is actively recruiting participants. Contact the research team at david.ostry@yale.edu for enrollment information.
Where is the NCT06491823 trial being conducted?
This trial is being conducted at New Haven, United States.
Who is sponsoring the NCT06491823 clinical trial?
NCT06491823 is sponsored by Yale University. The principal investigator is David Ostry at Yale University. The trial plans to enroll 120 participants.