NCT07449442 SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty
| NCT ID | NCT07449442 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Poznan University of Medical Sciences |
| Condition | Knee Osteoarthritis |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2026-03-01 |
| Primary Completion | 2026-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2026-03-01 with a primary completion date of 2026-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This randomized controlled trial evaluates the effect of ultrasound-guided iPACK block with Adductor Canal Block (ACB) on the Systemic Immune-Inflammation Index (SII) in elderly patients undergoing total hip arthroplasty under spinal anesthesia. SII, calculated as platelet × neutrophil / lymphocyte count, is used as a composite marker of perioperative inflammatory and immune response. The study investigates whether iPACK block with ACB attenuates the systemic inflammatory reaction to surgical trauma compared to sham block.
Eligibility Criteria
Inclusion Criteria: * Patients with ASA classification I-III * Aged 65-100 years * Who will be scheduled for hip arthroplasty under spinal anesthesia Exclusion Criteria: * Patients who have a history of bleeding diathesis * Take anticoagulant therapy * History of chronic pain before surgery * Multiple trauma * patients unable to assess their pain (dementia) * patients operated under general anesthesia * patients having an infection in the region of the procedure * the patient who does not accept the procedure
Contact & Investigator
Malgorzata Reysner, MD PhD
STUDY CHAIR
Poznań University of Medical Sciences
Frequently Asked Questions
Who can join the NCT07449442 clinical trial?
This trial is open to participants of all sexes, aged 65 Years or older, up to 100 Years, studying Knee Osteoarthritis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07449442 currently recruiting?
Yes, NCT07449442 is actively recruiting participants. Contact the research team at mreysner@ump.edu.pl for enrollment information.
Where is the NCT07449442 trial being conducted?
This trial is being conducted at Poznan, Poland.
Who is sponsoring the NCT07449442 clinical trial?
NCT07449442 is sponsored by Poznan University of Medical Sciences. The principal investigator is Malgorzata Reysner, MD PhD at Poznań University of Medical Sciences. The trial plans to enroll 60 participants.