| NCT ID | NCT07024420 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Zhongda Hospital |
| Condition | Postoperative Pulmonary Complications (PPCs) |
| Study Type | INTERVENTIONAL |
| Enrollment | 686 participants |
| Start Date | 2025-10-09 |
| Primary Completion | 2027-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 686 participants in total. It began in 2025-10-09 with a primary completion date of 2027-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this trial is to investigate whether sigh ventilation strategy, combining sigh breaths, low tidal volume, and moderate PEEP levels, protects against major pulmonary complications within the first 7 postoperative days after cardiac surgery, as compared with conventional ventilation strategy with low tidal volume, and moderate PEEP levels.
Eligibility Criteria
Inclusion Criteria: * 18 years of age or older; * Elective cardiac surgery with cardiopulmonary bypass, aortic clamp and cardioplegia; * Written informed consent is obtained from patients and/or their legal representatives. Exclusion Criteria: * Emergence surgery; * Left ventricular assist device implantation; * Planned thoracotomy with one lung ventilation; * Undergo concurrent surgical procedures outside cardiology; * Neuromuscular illness; * Mechanical ventilation within the last 2 weeks before surgery, include CPAP and NIV; * Preoperative shock; * Preoperative Hypoxemia (PaO2\<60mmHg OR SpO2\<90% on ambient air); * Preoperative left ventricular ejection fraction \< 40%; * Systolic pulmonary artery pressure \> 50 mmHg.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07024420 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Postoperative Pulmonary Complications (PPCs). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07024420 currently recruiting?
Yes, NCT07024420 is actively recruiting participants. Contact the research team at wang15zc@163.com for enrollment information.
Where is the NCT07024420 trial being conducted?
This trial is being conducted at Nanjing, China.
Who is sponsoring the NCT07024420 clinical trial?
NCT07024420 is sponsored by Zhongda Hospital. The trial plans to enroll 686 participants.