NCT05597410 Shanghai At Risk for Alzheimer's Disease: a Cohort Study
| NCT ID | NCT05597410 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ruijin Hospital |
| Condition | Alzheimer Disease |
| Study Type | OBSERVATIONAL |
| Enrollment | 3,418 participants |
| Start Date | 2022-03-01 |
| Primary Completion | 2029-03 |
Trial Parameters
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Brief Summary
The goal of this cohort study is to estimate the incidence of AD in the first-degree relatives of patients with AD. The main questions it aims to answer are: * cognitive changes of subjects at high risk of AD as ageing; * environmental and behavioral factors affecting AD incidence.
Eligibility Criteria
Inclusion Criteria: 1. the AD diagnostic criteria of probands meet the 2011 National Institute on Aging - Alzheimer's Association framework, and participants are the first-degree relatives (including parents, children and siblings of the same father and mother) of the proband; 2. not patients with dementia; 3. ≥ 50 years, males and females; 4. subjects have lived in Shanghai for more than 1 year and have no plan to move out of Shanghai within 5 years; 5. subjects are able to complete investigation, physical examination, imaging examination and biological specimen collection. Exclusion criteria: Individuals will be excluded if they have: 1. other diseases which could cause cognitive decline, e.g. cerebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease; 2. history of psychological disorders (according to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition); 3. uncorrectable visual or auditory impairment that hampers the completion of related examination.
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