Trial Parameters
Condition Postoperative Pain
Sponsor Washington University School of Medicine
Study Type OBSERVATIONAL
Phase N/A
Enrollment 210
Sex FEMALE
Min Age 11 Years
Max Age 16 Years
Start Date 2023-09-01
Completion 2027-07-01
All Conditions
Interventions
PainOpioid use
Brief Summary
Aim 1- To identify relationships between sex hormone levels and postoperative pain and opioid use. Aim 2: To determine whether the effects of testosterone on postoperative pain and opioid use are mediated by immune factors
Eligibility Criteria
Inclusion Criteria: Pediatric female patients between the ages 11-16 undergoing an orthopedic (trauma and non-trauma) surgical procedure involving a long bone or joint, or the spine, English speaking Exclusion Criteria: Pregnancy; Diagnosis of chronic pain, Psychiatric, developmental or neurological disorders, Disorders that are associated with pubertal maturation (e.g., precocious puberty).
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