NCT07403331 Severe Chronic Neuropathic Pain: A Treatment Bundle, Using Spinal Cord Stimulation and Multidisciplinary Treatment, to Reduce Pain and Improve Physical Function.
| NCT ID | NCT07403331 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Oslo University Hospital |
| Condition | Neuropathic Pain |
| Study Type | INTERVENTIONAL |
| Enrollment | 10 participants |
| Start Date | 2026-05-04 |
| Primary Completion | 2027-04-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 10 participants in total. It began in 2026-05-04 with a primary completion date of 2027-04-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
People with nerve damage can develop nerve pain. The pain can sometimes be severe and unpredictable, causing odd or alarming sensations - for example, lightning-like or electric shock feelings in the area served by the damaged nerve. The investigators will examine a treatment for nerve pain in the legs caused by nerve damage, which can occur after a herniated disc or a bone fracture, with or without surgery. Previous research suggests that spinal cord stimulation can relieve nerve pain in the legs after surgery or injury, but its effectiveness is still debated. Other studies show that multidisciplinary treatment helps people with long-term pain to improve their quality of life and to better cope in life. National and international guidelines recommend this kind of multidisciplinary care for long-term pain. There has yet been published research on spinal cord stimulation combined with multidisciplinary treatment as a bundle intervention. The investigators therefore want to find out whether this combined approach can reduce nerve pain in the legs and improve physical functioning.
Eligibility Criteria
Inclusion criteria: * Peripheral neuropathic pain in one or both legs for \>6 months due to: * (1) Post Spinal Pain Syndrome (type 1 or 2). * (2) Localized nerve damage. * The area of the neuropathic pain in the leg(s) must be the dominant pain component. * Age ranges from 18-60 years. * Previous standard conservative (or surgical) treatment attempted. * Opioid use within permissible limits at implantation time (daily opioid dose \<50 mg OMEQ). * Willingness to actively participate in the treatment bundle. * Living within reasonable travelling distance from Oslo. * Proficiency in understanding oral and written Norwegian, essential to benefit from the program that relies on mutual comprehension, nuanced conversation, and emotional expression, which are language-dependent. * Cognitive capacity to provide informed consent. * Ability to master the technical aspects of the SCS system (switching programs on the remote control). Exclusion criteria: * Currently undergoing the claims process for health benefits (e.g., disability pensions from NAV (Norwegian Labour and Welfare Administration). * Presenting a psychological or psychiatric disorder that may impact treatment efficacy. * Chronic generalized pain conditions. * Other pain conditions in the affected area, such as osteoarthritis. * Pregnancy.
Contact & Investigator
Lars-Petter Granan, Ph.D
PRINCIPAL INVESTIGATOR
Department of pain management and research, Oslo university hospital
Frequently Asked Questions
Who can join the NCT07403331 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Neuropathic Pain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07403331 currently recruiting?
Yes, NCT07403331 is actively recruiting participants. Contact the research team at chrekh@ous-hf.no for enrollment information.
Where is the NCT07403331 trial being conducted?
This trial is being conducted at Oslo, Norway.
Who is sponsoring the NCT07403331 clinical trial?
NCT07403331 is sponsored by Oslo University Hospital. The principal investigator is Lars-Petter Granan, Ph.D at Department of pain management and research, Oslo university hospital. The trial plans to enroll 10 participants.