NCT05814640 Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)
| NCT ID | NCT05814640 |
| Status | Recruiting |
| Phase | Phase 1, Phase 2 |
| Sponsor | First Affiliated Hospital of Chongqing Medical University |
| Condition | Depression |
| Study Type | INTERVENTIONAL |
| Enrollment | 520 participants |
| Start Date | 2023-02-20 |
| Primary Completion | 2026-12-31 |
Trial Parameters
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
Brief Summary
This project aims to investigate the effectiveness of existing common antidepressants and to provide new evidence for depressed children and adolescents who are not responding to their first treatment.
Eligibility Criteria
Inclusion Criteria: 1. Age 13 - 18 2. As assessed by K-SADS-PL, it meets the DSM-V criteria for MDD with non-psychotic symptoms 3. Score≥40 on the CDRS-R 4. Participants with suicidal ideation are eligible, as long as clinicians consider outpatient treatment to be safe 5. Sufficient audio-visual level to complete this study 6. Written informed consent was obtained from patients and at least one of their parents Exclusion Criteria: 1. History of bipolar disorder, schizophrenia, autism, eating disorders, primary obsessive compulsive disorder, pervasive developmental disorder, or psychosis not otherwise specified 2. History of serious physical illnesses 3. Substance abuse or dependence 4. Current depressive episode with clear suicidal plans or suicidal behavior 5. Requires inpatient treatment for psychiatric disorders 6. Severe mental disorders requiring 7. 2 or more failed trials of antidepressant drugs: each trial for at least 8 weeks, with the last 4 weeks at full dose (e.g. fluoxetine
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.