Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease
Trial Parameters
Brief Summary
The investigators are investigating the brain activity associated with sensory information in movement disorders in order to improve treatment of these symptoms beyond what is currently available.
Eligibility Criteria
Inclusion criteria (PD participants): 1. Age \>18 years 2. Clinically definite, advanced idiopathic PD based on consensus criteria. 3. Normal, or essentially normal, preoperative brain MRI. 4. Patient is available for follow-up visits over the length of the study 5. Patient has elected to undergo DBS surgery as part of routine care, and subthalamic nucleus (STN) is determined as the appropriate surgical target Inclusion criteria (control participants): 1. Age \>18 years. 2. No diagnosis of PD, other movement disorder, or other significant neurological disease. Exclusion criteria (PD participants): 1. Age \<18 years. 2. Medical contraindications such as current uncontrolled hypertension, heart disease, coagulopathy, or other conditions that might increase the risk of surgery 3. Diagnosis or suspicion of atypical Parkinsonism (PSP, MSA, CBD) or drug-induced Parkinsonism, or significant neurological disease other than PD. 4. Diagnosis of psychogenic movement disorder based on consensus cr