SAS 1: Develop Ocular Disease (OSD) Diagnostic, Algorithms, and Management Protocols for Cataract Surgery
Trial Parameters
Brief Summary
Patient: Tear film issues resulting in poor visual outcomes are a major cause of dissatisfaction after cataract surgery. There is no universal best preoperative algorithm for managing the ocular surface prior to surgery. Industry: Recent advances in tear/cornea imaging and refractive cataract surgery such as multifocal intraocular lenses will be advantageous to patients only if tear film issues can be addressed. Society: Cataract surgery is the most common ophthalmic surgery done in Singapore and worldwide. Improving vision by attending to tear film problems improves quality of life.
Eligibility Criteria
Inclusion Criteria: * Inclusion criteria for dry eye (participant must meet at least 1 of the inclusion criteria below): 1. Symptomatic for dry eye based on DEQ5 (\>6) and \[either TBUT less than 5 s or staining \>grade 1 in any zone of the cornea\] 2. Either use of diquasfosol, cyclosporine eyedrops or tacrolimus eyedrops for dry eye disease in the last 2 weeks (and previously started for more than 2 months), OR current and visible lower punctal plugs in at least one eye Inclusion criteria to fulfil all for controls (patients w/o dry eye): 1. DEQ5 \<=6. 2. Staining \< grade 1 in at least one corneal zone. 3. Not using diquasfosol, cyclosporine, tacrolimus in last 2 months. 4. No visible punctal plugs. Exclusion Criteria: * If there is another ocular condition which affects vision as much as cataract: active corneal stromal disease or scar or significant corneal endothelial disease * Known diagnosis of active thyroid dysfunction, Sjogren disease and rheumatoid arthritis * Intraocular s