NCT07323264 SAS 1: Develop Ocular Disease (OSD) Diagnostic, Algorithms, and Management Protocols for Cataract Surgery
| NCT ID | NCT07323264 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Louis Tong |
| Condition | Dry Eye |
| Study Type | OBSERVATIONAL |
| Enrollment | 110 participants |
| Start Date | 2025-06-27 |
| Primary Completion | 2027-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 110 participants in total. It began in 2025-06-27 with a primary completion date of 2027-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Patient: Tear film issues resulting in poor visual outcomes are a major cause of dissatisfaction after cataract surgery. There is no universal best preoperative algorithm for managing the ocular surface prior to surgery. Industry: Recent advances in tear/cornea imaging and refractive cataract surgery such as multifocal intraocular lenses will be advantageous to patients only if tear film issues can be addressed. Society: Cataract surgery is the most common ophthalmic surgery done in Singapore and worldwide. Improving vision by attending to tear film problems improves quality of life.
Eligibility Criteria
Inclusion Criteria: * Inclusion criteria for dry eye (participant must meet at least 1 of the inclusion criteria below): 1. Symptomatic for dry eye based on DEQ5 (\>6) and \[either TBUT less than 5 s or staining \>grade 1 in any zone of the cornea\] 2. Either use of diquasfosol, cyclosporine eyedrops or tacrolimus eyedrops for dry eye disease in the last 2 weeks (and previously started for more than 2 months), OR current and visible lower punctal plugs in at least one eye Inclusion criteria to fulfil all for controls (patients w/o dry eye): 1. DEQ5 \<=6. 2. Staining \< grade 1 in at least one corneal zone. 3. Not using diquasfosol, cyclosporine, tacrolimus in last 2 months. 4. No visible punctal plugs. Exclusion Criteria: * If there is another ocular condition which affects vision as much as cataract: active corneal stromal disease or scar or significant corneal endothelial disease * Known diagnosis of active thyroid dysfunction, Sjogren disease and rheumatoid arthritis * Intraocular surgery within the previous 6 months * Laser-assisted in situ keratomileusis or pterygium surgery within the previous 3 months * Central nervous system and hormonal drugs required within the last month and during the study * Active ocular infection, inflamed chalazion, or presence of pterygium * Glaucoma which requires topical anti-glaucoma medications * Any need to wear contact lens during the study * Having issues which make it difficult to follow up (eg., wheelchair, etc) * Pregnant and breast-feeding woman
Contact & Investigator
Louis Tong, PhD
PRINCIPAL INVESTIGATOR
Singapore Eye Research Institute
Frequently Asked Questions
Who can join the NCT07323264 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, up to 99 Years, studying Dry Eye. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07323264 currently recruiting?
Yes, NCT07323264 is actively recruiting participants. Contact the research team at louis.tong.h.t@singhealth.com.sg for enrollment information.
Where is the NCT07323264 trial being conducted?
This trial is being conducted at Singapore, Singapore.
Who is sponsoring the NCT07323264 clinical trial?
NCT07323264 is sponsored by Louis Tong. The principal investigator is Louis Tong, PhD at Singapore Eye Research Institute. The trial plans to enroll 110 participants.