NCT06701487 Role of Pavlovian Mechanisms for Control Over Substance Use

Trial Parameters

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Brief Summary

During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs between alcohol use disorder (AUD) and control subjects. Preliminary analyses of the full transfer task indicate that AUD participants exhibit a stronger specific PIT effect compared to controls. Based on these findings, the investigators want to compare specific and general PIT effects in patients with moderate to severe substance use disorders (alcohol, cannabis, methamphetamine, amphetamine and cocaine) to healthy controls on the behavioral and neural level (fMRI).

Eligibility Criteria

Inclusion Criteria: * Men and women between 18-65 years of age, * AUD, and/or SUD subjects only: meet 4 or more criteria for DSM-5 alcohol-related and/or substance-related (cannabis, amphetamine, methamphetamine or cocaine disorder (not requiring withdrawal as assessed by an independent psychiatrist), * Currently using alcohol without a desire for abstinence * Ability to consent to the study and complete the questionnaires. * Sufficient language(German) and motor skills for using PC * existing health insurance Exclusion Criteria: * Lifetime diagnosis of DSM-5 bipolar disorder or schizophrenia or schizophrenia spectrum disorder (if induced by drugs, it should happen more than a month ago) * Current threshold DSM-5 diagnosis of major depressive disorder, or presence of suicidal intention * High risk (≤ 26) ASSIST scores in other substances other than alcohol, amphetamine, methamphetamine, cannabis, cocaine, tobacco * History of traumatic brain injury or severe neurological disease (such

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