NCT07550400 Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients
| NCT ID | NCT07550400 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ain Shams University |
| Condition | Septic Shock |
| Study Type | OBSERVATIONAL |
| Enrollment | 40 participants |
| Start Date | 2026-05-03 |
| Primary Completion | 2026-11-02 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 40 participants in total. It began in 2026-05-03 with a primary completion date of 2026-11-02.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Fluid replacement is considered the cornerstone of hemodynamic management in critically ill patients especially in patients with septic shock. However, only about 50% of critically ill hemodynamically unstable patients are responsive to fluids. Consequently, the resuscitation of critically ill patients requires an accurate assessment of the patients' intravascular volume status and their volume responsiveness. In this study, we will compare the efficacy of carotid artery flow to echo left ventricular end diastolic volume as a predictive value for fluid resuscitation in septic shock patients.
Eligibility Criteria
Inclusion Criteria: * ▪ Age:18-50 years old * Sex: both males \&females. * Patients diagnosed with septic shock according to SOFA score more than or equal 1 * Presence of at least one sign of acute circulatory failure from: 1. Low blood pressure (mean arterial pressure \<65 mmHg and / or systolic \<90 mmHg). 2. Tachycardia\> 120 bpm without other obvious cause of circulatory failure. 3. Oliguria \<1 ml / kg during the last hour suggestive of circulatory failure. 4. Blood hyperlactatemia \> 2mmol / l without other obvious cause a systemic circulatory failure. 5. Another sign justifying, for example vascular increase capillary refill time more than 2 seconds. Exclusion Criteria: * ▪ Known significant valvular heart disease (sever aortic insufficiency or stenosis) * Known carotid artery stenosis \>50% or previous carotid surgery * Clear contraindication to the carotid artery Doppler such as wound or infection or complete or partial occlusion of the carotid artery. * Arrhythmias affect stroke volume assessment (atrial fibrillation, frequent PVCs) * Dilated cardiomyopathy. * Poor transthoracic echocardiographic window * Patient refusal
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07550400 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 50 Years, studying Septic Shock. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07550400 currently recruiting?
Yes, NCT07550400 is actively recruiting participants. Contact the research team at baheya.hesham.kamel@gmail.com for enrollment information.
Where is the NCT07550400 trial being conducted?
This trial is being conducted at Cairo, Egypt.
Who is sponsoring the NCT07550400 clinical trial?
NCT07550400 is sponsored by Ain Shams University. The trial plans to enroll 40 participants.