NCT07567053 Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Palsy: TMS-EEG Study
| NCT ID | NCT07567053 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Cook Children's Health Care System |
| Condition | Cerebral Palsy |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2026-05-27 |
| Primary Completion | 2028-05-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2026-05-27 with a primary completion date of 2028-05-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This project examines the use of repetitive transcranial magnetic stimulation (rTMS) as a therapeutic approach to improve motor function in children with cerebral palsy (CP). By applying 6-Hz primed low and high-frequency rTMS and measuring brain responses through TMS-EEG, the study aims to enhance neural plasticity and motor recovery. The goal is to promote faster rehabilitation and reduce long-term healthcare needs.
Eligibility Criteria
Inclusion Criteria (CP): * Aged 6 - 20 years, * A confirmed diagnosis of CP by a specialized professional (pediatric neurologist, PM\&R physician, neonatal developmental specialist, or neonatologist) is a prerequisite for participation, * Classified as high functioning (Level I, II, or III) according to the Gross Motor Function Classification System (GMFCS), * Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study, * Preserved vision and hearing (with or without correction). Inclusion Criteria (TD): * Aged 6 - 20 years * Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study, * Preserved vision and hearing (with or without correction). Exclusion Criteria (CP): * Syndromic or genetic brain-related associations, * History of major trauma or brain surgery, * Inability to remain still, * History of Epilepsy, * Severe coexisting sickness or illness unrelated to CP or unstable medical conditions such as pneumonia, * Modified Ashworth Scale: Shoulder, elbow, and wrist scores more than 3, * Limb contractures caused by any other injury except CP, * Severe movement disorders that prevent intentional limb movements, such as choreoathetosis, or ballismus, * Contraindications for rTMS include non-removable metallic objects close to a coil and implanted electronic devices, such as cochlear implants and pacemakers. Exclusion Criteria (TD): * Syndromic or genetic brain-related associations, * History of major trauma or brain surgery, * Inability to remain still, * History of Epilepsy, * Severe coexisting sickness or illness unrelated to CP or unstable medical conditions such as pneumonia, * Limb contractures caused by injury, * Severe movement disorders that prevent intentional limb movements, such as choreoathetosis, or ballismus, * Contraindications for rTMS include non-removable metallic objects close to a coil and implanted electronic devices, such as cochlear implants and pacemakers.
Contact & Investigator
Christos Papadelis, PhD
PRINCIPAL INVESTIGATOR
Cook Children's Health Care System
Frequently Asked Questions
Who can join the NCT07567053 clinical trial?
This trial is open to participants of all sexes, aged 6 Years or older, up to 20 Years, studying Cerebral Palsy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07567053 currently recruiting?
Yes, NCT07567053 is actively recruiting participants. Contact the research team at Christos.Papadelis@cookchildrens.org for enrollment information.
Where is the NCT07567053 trial being conducted?
This trial is being conducted at Fort Worth, United States.
Who is sponsoring the NCT07567053 clinical trial?
NCT07567053 is sponsored by Cook Children's Health Care System. The principal investigator is Christos Papadelis, PhD at Cook Children's Health Care System. The trial plans to enroll 60 participants.
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