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Recruiting Phase 4 NCT06417645

Re-evaluation of the Effect Site Model of the PKPD Propofol Eleveld Model

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Trial Parameters

Condition Healthy
Sponsor Universidad del Desarrollo
Study Type INTERVENTIONAL
Phase Phase 4
Enrollment 24
Sex ALL
Min Age 18 Years
Max Age 65 Years
Start Date 2013-09-01
Completion 2023-09-15
All Conditions
Interventions
fixed propofol infusion 15 mg/kg/h until 1% BSR (burst suppression ratio)

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Brief Summary

in healthy patients undergoing elective surgery, after a very slow induction, using Eleveld's kinetics as a reference, after loss of consciousness (LOC) and intubation, proceed to infuse propofol until 1% burst suppression ratio is obtained. Then return to the LOC concentration. The BISindex predicted by the model and the real one will be evaluated. The evolution of spectral density frequencies over time will also be evaluated.

Eligibility Criteria

Inclusion Criteria: * ASA I-II patients between 18 and 60 years of age, who undergo elective surgery in the central ward of the Hospital Base San José Osorno, Chile. Consecutive patients from the beginning of the study up to 12 months from the admission of the first patient. Exclusion Criteria: * Emergency surgery patient. * Patients with dementia, delirium or altered state of consciousness. * Full stomach or risk of aspiration. * Allergic to propofol.

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