NCT07727265 PyroEVs/PLIN3 Mediate Lipid Droplet-Mitochondrial Coupling in Sepsis Endothelial Injury
| NCT ID | NCT07727265 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Zhongda Hospital |
| Condition | Sepsis |
| Study Type | OBSERVATIONAL |
| Enrollment | 180 participants |
| Start Date | 2024-07-01 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 180 participants in total. It began in 2024-07-01 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Objective: To investigate the correlation of PyroEVs and PLIN3 with the severity and prognosis of sepsis patients. Participants: Sepsis patients meeting the Sepsis 3.0 diagnostic criteria admitted to the Intensive Care Unit of Zhongda Hospital affiliated with Southeast University, as well as healthy volunteers. Inclusion Criteria: 1. Presence of confirmed or suspected infection; 2. Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline; 3. Signed informed consent. Exclusion Criteria: Age \< 18 or \> 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury. Primary outcome: 28-day mortality, SOFA score
Eligibility Criteria
Inclusion Criteria: * a. Presence of confirmed or suspected infection; b. Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline; c. Signed informed consent. Exclusion Criteria: * Age \< 18 or \> 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.
Contact & Investigator
Yi Yang
PRINCIPAL INVESTIGATOR
Zhongda Hospital
Frequently Asked Questions
Who can join the NCT07727265 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Sepsis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07727265 currently recruiting?
Yes, NCT07727265 is actively recruiting participants. Contact the research team at afei0312@163.com for enrollment information.
Where is the NCT07727265 trial being conducted?
This trial is being conducted at Nanjing, China.
Who is sponsoring the NCT07727265 clinical trial?
NCT07727265 is sponsored by Zhongda Hospital. The principal investigator is Yi Yang at Zhongda Hospital. The trial plans to enroll 180 participants.