NCT05304286 Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults
| NCT ID | NCT05304286 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Massachusetts General Hospital |
| Condition | Chronic Post-surgical Pain |
| Study Type | INTERVENTIONAL |
| Enrollment | 110 participants |
| Start Date | 2022-04-07 |
| Primary Completion | 2026-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 110 participants in total. It began in 2022-04-07 with a primary completion date of 2026-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The current project will (1) enhance our understanding of the neurobiology of chronic post-surgical pain (CPSP); (2) provide a metric to follow patients with CPSP in the clinic; (3) provide a metric for those who will chronify; and (4) understand the age-related differences in CPSP. Ultimately, an improved comprehension of mechanisms linked to CPSP will provide finer tools for optimizing the selection of treatments for individual patients. Moreover, data that demonstrates the underlying pathobiological pain mechanism(s) active in CPSP, particularly those non-responsive to current therapies, may be used to validate novel strategies both pharmacological and non-pharmacological.
Eligibility Criteria
Inclusion Criteria: --Females and males aged 12 and older who have previously undergone surgery at least 6 months ago and have chronic post surgical pain (3 months after surgery or longer) Exclusion Criteria: * Inability to speak sufficient English or another language that can be interpreted orally and for questionnaires with the research team * Severe cognitive impairment by history (e.g., intellectual disability, severe head injury) * Patients with significant psychiatric disorders * Use of illegal hard drugs including MDMA, heroin, methamphetimes, amphetamines, cocaine, ketamine, benzodiazepines, and phencyclidine. Absence of such drugs will be confirmed in a urine drug screen during the visit. If prescription medication includes any of these compounds, that medication is not exclusionary.
Contact & Investigator
Christine B. Sieberg
PRINCIPAL INVESTIGATOR
Massachusetts General Hospital
Frequently Asked Questions
Who can join the NCT05304286 clinical trial?
This trial is open to participants of all sexes, aged 12 Years or older, studying Chronic Post-surgical Pain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05304286 currently recruiting?
Yes, NCT05304286 is actively recruiting participants. Contact the research team at csieberg@mgh.harvard.edu for enrollment information.
Where is the NCT05304286 trial being conducted?
This trial is being conducted at Boston, United States.
Who is sponsoring the NCT05304286 clinical trial?
NCT05304286 is sponsored by Massachusetts General Hospital. The principal investigator is Christine B. Sieberg at Massachusetts General Hospital. The trial plans to enroll 110 participants.