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Recruiting NCT06309550

NCT06309550 Provocative Tests for HFpEF

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Clinical Trial Summary
NCT ID NCT06309550
Status Recruiting
Phase
Sponsor Istituto Auxologico Italiano
Condition Heart Failure With Preserved Ejection Fraction
Study Type OBSERVATIONAL
Enrollment 500 participants
Start Date 2023-03-10
Primary Completion 2028-03

Eligibility & Interventions

Sex All sexes
Min Age N/A
Max Age N/A
Study Type OBSERVATIONAL
Interventions
exercise test

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 500 participants in total. It began in 2023-03-10 with a primary completion date of 2028-03.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

Diagnosing heart failure with preserved ejection fraction (HFpEF) in patients complaining exertional breathlessness can be challenging: diagnostic algorithms and scores have low sensitivity, and ageing-associated comorbidities can complicate the interpretation of symptoms. Thus, exercise right heart catheterization (RHC) or invasive cardiopulmonary exercise test (iCPET) have been advocated as gold-standard methods for HFpEF diagnosis. However, exercise RHC and iCPET are still not widely standardized methods, with results mainly coming from US cohorts (that may differ from Italian cohorts), and other provocative tests (e.g. non-invasive CPET, passive leg raising) may offer complementary diagnostic information.

Eligibility Criteria

Inclusion Criteria: * dyspnea Exclusion Criteria: * known HFpEF

Contact & Investigator

Central Contact

Sergio Caravita, MD, PhD

✉ s.caravita@auxologico.it

📞 +39 02 619112930

Frequently Asked Questions

Who can join the NCT06309550 clinical trial?

This trial is open to participants of all sexes, studying Heart Failure With Preserved Ejection Fraction. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT06309550 currently recruiting?

Yes, NCT06309550 is actively recruiting participants. Contact the research team at s.caravita@auxologico.it for enrollment information.

Where is the NCT06309550 trial being conducted?

This trial is being conducted at Milan, Italy.

Who is sponsoring the NCT06309550 clinical trial?

NCT06309550 is sponsored by Istituto Auxologico Italiano. The trial plans to enroll 500 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: July 2026  ·  Data Methodology