NCT07883499 Prospective Study Protocol for Multiparametric PCCT Assessment of Early Ventricular Outcomes After CABG
| NCT ID | NCT07883499 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Xin Lou |
| Condition | Coronary Artery Bypass Grafting (CABG) Surgery |
| Study Type | OBSERVATIONAL |
| Enrollment | 150 participants |
| Start Date | 2025-10-10 |
| Primary Completion | 2029-10-10 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 150 participants in total. It began in 2025-10-10 with a primary completion date of 2029-10-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to learn whether information about heart muscle tissue from preoperative photon-counting CT, a newer type of CT scan, can help predict heart recovery 3 months after coronary artery bypass surgery. The study will include adults aged 18 years or older with coronary artery disease who are scheduled for coronary artery bypass surgery without another major heart operation. The main question it aims to answer is: \- Can heart muscle information from CT before surgery help predict the amount of blood remaining in the heart's left pumping chamber after it contracts, adjusted for body size, 3 months after surgery? This measurement is called the left ventricular end-systolic volume index and will be used to assess early changes in heart structure after surgery. Participants will: * Have photon-counting CT scans and heart ultrasound examinations before surgery, within 7 days after surgery, and approximately 3 months after surgery. * Have blood tests before surgery and within 7 days afterward to help researchers assess changes in heart muscle tissue. * Provide information about medications, hospital admissions, and their health during follow-up. Clinical doctors will determine surgery and treatment based on each participant's medical needs.
Eligibility Criteria
Inclusion Criteria: 1. Age ≥18 years and scheduled for isolated CABG. 2. Able to undergo the protocol-specified PCCT examinations after assessment by the clinical and imaging teams. 3. Able to understand the study and provide written informed consent, and willing to attend the 3-month postoperative follow-up. Exclusion Criteria: 1. Planned concomitant major cardiac surgery, such as valve or aortic surgery, that places the patient outside the target population of isolated CABG. 2. A clinically assessed contraindication to contrast-enhanced CT, including a severe iodinated contrast allergy that cannot be adequately managed, pregnancy, or another examination contraindication. 3. Clinical condition precluding research examinations, or a research workflow that could delay necessary treatment. 4. Unable to complete the informed consent process or explicitly unwilling to attend the required follow-up.
Contact & Investigator
Xin Lou
STUDY CHAIR
Department of Radiology, the First Medical Center of Chinese PLA General Hospital/ Chinese PLA Medical School, Beijing, China
Frequently Asked Questions
Who can join the NCT07883499 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 100 Years, studying Coronary Artery Bypass Grafting (CABG) Surgery. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07883499 currently recruiting?
Yes, NCT07883499 is actively recruiting participants. Contact the research team at fanxiaomeng@301hospital.com.cn for enrollment information.
Where is the NCT07883499 trial being conducted?
This trial is being conducted at Beijing, China.
Who is sponsoring the NCT07883499 clinical trial?
NCT07883499 is sponsored by Xin Lou. The principal investigator is Xin Lou at Department of Radiology, the First Medical Center of Chinese PLA General Hospital/ Chinese PLA Medical School, Beijing, China. The trial plans to enroll 150 participants.