| NCT ID | NCT06814275 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Wake Forest University Health Sciences |
| Condition | Stimulant Use |
| Study Type | INTERVENTIONAL |
| Enrollment | 189 participants |
| Start Date | 2025-04-29 |
| Primary Completion | 2028-05-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 189 participants in total. It began in 2025-04-29 with a primary completion date of 2028-05-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave. By learning more about how these processes work, the hope is to be able to develop better treatments to help with problems like depression and substance use. This study is intended for individuals that are HIV positive, currently taking prescription antiretroviral medications, and use stimulants. Through this intervention, the aim is to determine if this positive affect intervention can lead to reductions in stimulant use and depressed mood.
Eligibility Criteria
Inclusion Criteria: * 18-59 years old * Weekly use of stimulants reported in the past month or a score of 4 or more on the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) * Confirmed HIV diagnosis * Current receipt of daily oral antiretroviral therapy (ART) medication * English fluency/literacy Exclusion Criteria: * Acute brain infection (e.g., neurosyphilis, toxoplasmosis) * Acutely symptomatic bipolar I or psychotic disorder * Prescription for immunomodulatory medications or other immunotherapy * Any MRI contraindications * If applicable, on antidepressant medication regimen for at least 2 months
Contact & Investigator
Christina S Meade, PhD
PRINCIPAL INVESTIGATOR
Wake Forest University Health Sciences
Frequently Asked Questions
Who can join the NCT06814275 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 59 Years, studying Stimulant Use. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06814275 currently recruiting?
Yes, NCT06814275 is actively recruiting participants. Contact the research team at cmeade@wakehealth.edu for enrollment information.
Where is the NCT06814275 trial being conducted?
This trial is being conducted at Winston-Salem, United States.
Who is sponsoring the NCT06814275 clinical trial?
NCT06814275 is sponsored by Wake Forest University Health Sciences. The principal investigator is Christina S Meade, PhD at Wake Forest University Health Sciences. The trial plans to enroll 189 participants.