NCT06363253 Pilot Study of the Human Metagenome in Metabolic Diseases
| NCT ID | NCT06363253 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Sengkang General Hospital |
| Condition | Obesity |
| Study Type | OBSERVATIONAL |
| Enrollment | 600 participants |
| Start Date | 2023-08-14 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 600 participants in total. It began in 2023-08-14 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a cohort study to understand the role of the human metagenome, and associated metabolites, in health and in various diseased states, in particular obesity as well as sarcopenia. Recruited participants will have their fecal, salivary, urine, serum, and in certain instances, mucosal samples taken, for metagenomic sequencing and metabolite testing. We hope to uncover various differences and signatures in the metagenome and metabolome in various diseased states, with potential future therapeutic applications in personalised medicine.
Eligibility Criteria
Inclusion Criteria (obese cohort): * Obese (BMI\>27.5kg/m2) Inclusion Criteria (sarcopenic cohort): * Sarcopenic patients, defined as 1) low handgrip strength (\<26 for males; \<18kg for females), AND/OR low gait speed (\<0.8m/s) AND low muscle mass (\<7.0kg/m2 for males; \<5.7kg/m2 for females) Inclusion Criteria (control cohort): \- Healthy subjects without sarcopenia, and not obese (BMI\<27.5kg/m2) Exclusion Criteria: * No informed consent * Presence of intestinal stoma, hence inability to collect fecal samples
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06363253 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, up to 99 Years, studying Obesity. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06363253 currently recruiting?
Yes, NCT06363253 is actively recruiting participants. Contact the research team at chue.koy.min@singhealth.com.sg for enrollment information.
Where is the NCT06363253 trial being conducted?
This trial is being conducted at Singapore, Singapore.
Who is sponsoring the NCT06363253 clinical trial?
NCT06363253 is sponsored by Sengkang General Hospital. The trial plans to enroll 600 participants.
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