NCT07503509 Physiological Study of High PEEP in Noninvasive Ventilation
| NCT ID | NCT07503509 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Chongqing Medical University |
| Condition | Respiratory Failure With Hypoxia |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2024-03-26 |
| Primary Completion | 2026-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2024-03-26 with a primary completion date of 2026-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
To investigate the physiological effects of high positive end-expiratory pressure (PEEP) during noninvasive ventilation in patients with hypoxemic respiratory failure, and to elucidate the mechanisms underlying high PEEP-induced improvement in oxygenation.
Eligibility Criteria
Inclusion Criteria: 1. Age ≥ 18 years 2. PaCO₂ ≤ 50 mmHg 3. PaO₂/FiO₂ ≤ 300 mmHg 4. Use of a noninvasive ventilator with esophageal pressure monitoring capability (e.g., Mindray SV70) - Exclusion Criteria: 1. Respiratory failure caused by heart failure, asthma, or acute exacerbation of chronic obstructive pulmonary disease (COPD) (COPD as a comorbidity may be included) 2. Pneumothorax 3. Patients who refuse to participate in this trial -
Contact & Investigator
Jun Duan, MD
PRINCIPAL INVESTIGATOR
First Affiliated Hospital of Chongqing Medical University
Frequently Asked Questions
Who can join the NCT07503509 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 100 Years, studying Respiratory Failure With Hypoxia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07503509 currently recruiting?
Yes, NCT07503509 is actively recruiting participants. Contact the research team at duanjun412589@163.com for enrollment information.
Where is the NCT07503509 trial being conducted?
This trial is being conducted at Chongqing, China.
Who is sponsoring the NCT07503509 clinical trial?
NCT07503509 is sponsored by Chongqing Medical University. The principal investigator is Jun Duan, MD at First Affiliated Hospital of Chongqing Medical University. The trial plans to enroll 50 participants.