NCT07007715 Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula
| NCT ID | NCT07007715 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Taiwan University Hospital |
| Condition | Extubation Readiness |
| Study Type | INTERVENTIONAL |
| Enrollment | 480 participants |
| Start Date | 2025-06-05 |
| Primary Completion | 2028-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 480 participants in total. It began in 2025-06-05 with a primary completion date of 2028-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this randomized trial is to compare four different flow-setting approaches for post-extubation use of high-flow nasal cannula (HFNC). Selecting the appropriate flow rate when initiating HFNC oxygen therapy is both crucial and challenging for clinicians, as the physiological benefits of HFNC depend significantly on the flow rate. To date, there are no guidelines or consensus on flow-rate setting and weaning for HFNC oxygen therapy. The investigators hypothesized that physiological marker-guided flow setting using peak tidal inspiratory flow (PTIF) or PaO₂/FiO₂ ratios lead to better extubation outcomes as compared to empirical flow setting of 40 L/min or 60 L/min. Participants will be randomly assigned to one of four study groups with different flow setting strategies summarized as follows: (1) Setting flow at 40 L/min, (2) Setting flow at 5 L/min above the peak tidal inspiratory flow, up to a maximum of 60 L/min. (3) Setting flow according to P/F ratio prior to extubation. Flow will be set at 60, 50 40 L/min if P/F ratio \<250 mmHg, 250-300 mmHg and \>300 mmHg, respectively. (4) Setting flow at 60 L/min.
Eligibility Criteria
Inclusion Criteria: * Intubated and receiving mechanical ventilation for more than 24 hours * Ready for planned extubation after passing a spontaneous breathing trial * PaO2/FiO2 \<350 mmHg on the day of extubation Exclusion Criteria: * Age \<18 years * On do-not-reintubate code * Pregnant women * Having tracheostomies * Infeasibility of using HFNC * Planning to use preventive NIV after extubation by the primary care team * Life expectancy less than one month
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07007715 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Extubation Readiness. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07007715 currently recruiting?
Yes, NCT07007715 is actively recruiting participants. Contact the research team at syruan@ntu.edu.tw for enrollment information.
Where is the NCT07007715 trial being conducted?
This trial is being conducted at Taipei, Taiwan.
Who is sponsoring the NCT07007715 clinical trial?
NCT07007715 is sponsored by National Taiwan University Hospital. The trial plans to enroll 480 participants.