NCT05603520 Phenotyping Heterogeneity and Regionality of the Aorta
| NCT ID | NCT05603520 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Heinrich-Heine University, Duesseldorf |
| Condition | Large Artery Stiffness |
| Study Type | OBSERVATIONAL |
| Enrollment | 300 participants |
| Start Date | 2020-10-18 |
| Primary Completion | 2027-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 300 participants in total. It began in 2020-10-18 with a primary completion date of 2027-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aorta distributes cardiac stroke volume into the whole body through its finetuned conductance function, that is propagation and modulation of flow pattern. Physicomechanic properties of the aortic wall assure continuous and homogenous blood flow distribution to organs. The physicomechanic properties of the aortic wall are heterotopic: The collagen/elastin ratio doubles in the abdominal aorta as compared to the thoracic aorta. Malfunction of aortic conduction due to large artery stiffening (LAS) leads to premature wave reflection and excess pulsatility which translate into organ damage in low-resistance beds. The regional heterogeneity of aortic physicomechanic properties and their histomorphological substrate leading to altered regional hemodynamics are not well investigated. Within the PHaRAo population, there is a spectrum of higher and lower risk patients. The aim of this cohort study is to collect prospectively and systematically clinical research data from PHaRAo patients. This cohort study is an open-end observational study to identify master switches in aortic disease
Eligibility Criteria
1. apparently healthy volunteers Inclusion Criteria: • Healthy volunteers Exclusion Criteria: * \< 18 years * Active Medication * Cardiovascular Disease * MRI not possible 2. Patients with Aortic Stenosis Inclusion Criteria: • Patients suffering from 3rd drgree Aortic Stenosis Exclusion Criteria: * \< 18 years * MRI not possible 3. Patients with Aortic Aneurysms Inclusion Criteria: • Patients suffering from Aortic Aneurysms Exclusion Criteria: * \< 18 years * MRI not possible
Contact & Investigator
Malte Kelm, MD
STUDY CHAIR
Division of Cardiology, Pulmonary Disease and Vascular Medicine
Frequently Asked Questions
Who can join the NCT05603520 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Large Artery Stiffness. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05603520 currently recruiting?
Yes, NCT05603520 is actively recruiting participants. Contact the research team at Christine.Quast@med.uni-duesseldorf.de for enrollment information.
Where is the NCT05603520 trial being conducted?
This trial is being conducted at Düsseldorf, Germany.
Who is sponsoring the NCT05603520 clinical trial?
NCT05603520 is sponsored by Heinrich-Heine University, Duesseldorf. The principal investigator is Malte Kelm, MD at Division of Cardiology, Pulmonary Disease and Vascular Medicine. The trial plans to enroll 300 participants.