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Recruiting Phase 1 NCT07469163

Phase I Split-Belt Treadmill Dosing for Subacute Stroke

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Trial Parameters

Condition Subacute Stroke
Sponsor University of Calgary
Study Type INTERVENTIONAL
Phase Phase 1
Enrollment 72
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2026-03-01
Completion 2026-08-31
Interventions
Split-Belt Treadmill

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Brief Summary

After experiencing a stroke, many individuals encounter difficulties with walking and balance, which can significantly impact their independence. Recent studies have indicated that split-belt treadmill (SBT) training is effective for improving gait metrics, including walking speed and step length asymmetry. The SBT allows each leg to move at different speeds, which has been shown to help chronic stroke survivors learn to walk more symmetrically. However, there is limited knowledge about the dose participants should receive and the safety of SBT training in the early stages of recovery, which is a crucial period for rehabilitation. To address this gap, we are evaluating an innovative SBT with virtual reality (VR) features at the Foothills Medical Center. Our objective is to conduct a study to determine the amount of SBT training patients can tolerate in a day. In this study, stroke survivors will engage in a series of walking exercises on the SBT. We will escalate the duration of SBT walking until participants reach a point where they can no longer continue due to dose-limiting criteria such as fatigue or discomfort. The findings from this initial phase will guide future larger trials to explore the effectiveness of this training method. Ultimately, we aspire to improve rehabilitation strategies for stroke survivors, assisting them in regaining mobility and enhancing their quality of life more effectively.

Eligibility Criteria

Inclusion Criteria: * Ischemic or hemorrhagic stroke survivors * First stroke * Over 18 years old * Between one week and three months post-stroke * can understand task instructions. Exclusion Criteria: * History of significant neurological diseases (e.g. Multiple Sclerosis, Parkinson's disease) * Orthopedic issues in lower extremities (e.g. severe knee Osteoarthritis) * Excessive pain preventing participants from participating in treadmill-based activities * Cerebellar stroke * Body weight more than 560 lbs (this exceeds the weight limit of the support harness)

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