NCT04151940 PET/CT Changes During Chemoimmunotherapy and Radiation Therapy in Patients With Stage IV Non-small Cell Lung Cancer
| NCT ID | NCT04151940 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Washington |
| Condition | Metastatic Lung Non-Small Cell Carcinoma |
| Study Type | INTERVENTIONAL |
| Enrollment | 80 participants |
| Start Date | 2019-09-26 |
| Primary Completion | 2027-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 80 participants in total. It began in 2019-09-26 with a primary completion date of 2027-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study investigates the changes in positron emission tomography (PET)/computed tomography (CT) imaging scans during chemoimmunotherapy and radiation therapy treatment in patients with stage IV non-small cell lung cancer. Analyzing changes in PET/CT imaging scans may help doctors assess and predict patterns of cancer response to chemoimmunotherapy and radiation therapy.
Eligibility Criteria
Inclusion Criteria: * Histologically-confirmed or cytologically-confirmed metastatic NSCLC in patients who have not received chemotherapy or immunotherapy for their advanced disease (stage IV or recurrent, using the American Joint Committee on Cancer \[AJCC\]/Union for International Cancer Control \[UICC\] 8th edition for staging) * Evidence of stage IV disease on imaging by CT, PET/CT, or magnetic resonance imaging (MRI) * Plan to treat with a platinum doublet with a PD1 or PDL1 inhibitor * Adjuvant chemotherapy or concurrent chemoradiation for early stage disease does not count as prior therapy unless subject progressed within 6 months of completion of regimen. * Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1, at treating physician's discretion * Subjects must be ≥ 18 years of age * Patients with known activating mutations in EGFR, BRAF or known translocation in ALK or ROS-1 are eligible provided they have progressed on or were intolerant to Food and Drug Administration (FDA) approved targeted therapy * Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2 * Creatinine =\< 2 mg/dL or creatinine clearance \> 50 mL/min * Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 5x institutional upper limit of normal * Total bilirubin =\< 1.5 mg/dL * Absolute neutrophil count (ANC) \>= 1.5 x 10\^9/L (\>= 1500 per mm\^3) * Platelet count \>= 100 x 10\^9/L (\>=100,000 per mm\^3) * Capability to understand and comply with the protocol requirements and signed informed consent documents Exclusion Criteria: * Any known additional malignancy (with exception of non-melanoma skin cancer, in-situ breast cancer, low risk prostate cancer, or a malignancy diagnosed \>= 3 years prior to the current NSCLC diagnosis and with no evidence of requiring active treatment) * Had prior treatment with an anti-PD-1, or PD-L1 or PD-L2 agent or an antibody targeting other immuno-regulatory receptors or mechanisms * Has any serious or uncontrolled active infection that could create false positives on a PET/CT scan, in the opinion of the treating investigator * Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator * Has an active autoimmune disease currently requiring systemic treatment (e.g. disease modifying agents, corticosteroids or immunosuppressive drugs) \*\*Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment * Has known, active, and symptomatic central nervous system (CNS) metastases and/or carcinomatous meningitis * Patients with stable or previously treated brain metastases are eligible as long as they are not receiving more than 10 mg of prednisone, or equivalent, per day
Contact & Investigator
Lei Deng, MD
PRINCIPAL INVESTIGATOR
Fred Hutch/University of Washington Cancer Consortium
Frequently Asked Questions
Who can join the NCT04151940 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Metastatic Lung Non-Small Cell Carcinoma. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04151940 currently recruiting?
Yes, NCT04151940 is actively recruiting participants. Contact the research team at srbowen@uw.edu for enrollment information.
Where is the NCT04151940 trial being conducted?
This trial is being conducted at Seattle, United States.
Who is sponsoring the NCT04151940 clinical trial?
NCT04151940 is sponsored by University of Washington. The principal investigator is Lei Deng, MD at Fred Hutch/University of Washington Cancer Consortium. The trial plans to enroll 80 participants.