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stage iv lung cancer ajcc v8

Total Trials
8
Recruiting Now
8
Trial Phases
Phase 3, Phase 1, Phase 1, Phase 2

Cancer clinical trials represent the largest single category of recruiting studies worldwide, encompassing everything from early-phase safety studies of novel oncology drugs to large Phase 3 comparisons against current standard-of-care chemotherapy regimens. The field has accelerated dramatically with the rise of immunotherapy, targeted therapies, and CAR-T cell treatments that have transformed outcomes for previously untreatable malignancies.

Trials include checkpoint inhibitors (PD-1/PD-L1 agents), KRAS inhibitors, ADC (antibody-drug conjugates), combination chemotherapy regimens, radiation protocols, and surgical technique comparisons. Many trials stratify by biomarker status (PD-L1 expression, TMB, MSI-H) to identify patients most likely to benefit.

The NCI, pharmaceutical sponsors, and academic cancer centers collectively fund thousands of oncology trials annually across every cancer type.

Frequently Asked Questions — stage iv lung cancer ajcc v8 Clinical Trials

How many clinical trials are currently recruiting for stage iv lung cancer ajcc v8?
ClinicalMetric currently tracks 8 actively recruiting clinical trials for stage iv lung cancer ajcc v8, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 8. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.
What trial phases are available for stage iv lung cancer ajcc v8?
stage iv lung cancer ajcc v8 research spans Phase 1 (2 trials), Phase 2 (4 trials), Phase 3 (2 trials). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.
How do I find out if I qualify for a stage iv lung cancer ajcc v8 clinical trial?
Eligibility criteria for stage iv lung cancer ajcc v8 trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.
Trial Phases
Phase 1
2
Phase 2
4
Phase 3
2
Top Sponsors
Dwight Owen 2 trials
National Cancer Institute (NCI) 1 trial
Mayo Clinic 1 trial
Emory University 1 trial
City of Hope Medical Center 1 trial

Recruiting Clinical Trials

NCT04181060 Phase 3
Recruiting

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

Enrollment
300 pts
Location
United States
Sponsor
National Cancer Institute (NCI...
View Trial →
NCT06616623 Phase 1
Recruiting

Vismodegib and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Enrollment
24 pts
Location
United States
Sponsor
Dwight Owen
View Trial →
NCT05269381 Phase 1, Phase 2
Recruiting

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

Enrollment
132 pts
Location
United States
Sponsor
Mayo Clinic
View Trial →
NCT04919382 Phase 2
Recruiting

Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer

Enrollment
56 pts
Location
United States
Sponsor
Dwight Owen
View Trial →
NCT06731270 Phase 2
Recruiting

Diclofenac for the Treatment of Patients With Metastatic Non-small Cell Lung Cancer on Single Agent Immunotherapy

Enrollment
20 pts
Location
United States
Sponsor
Emory University
View Trial →
NCT06910761 Phase 2
Recruiting

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

Enrollment
35 pts
Location
United States
Sponsor
City of Hope Medical Center
View Trial →
NCT06500481 Phase 3
Recruiting

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

Enrollment
115 pts
Location
United States
Sponsor
NRG Oncology
View Trial →
NCT03948100
Recruiting

Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non-small Cell Lung or Esophageal Cancer Undergoing Radiotherapy and Their Caregivers

Enrollment
400 pts
Location
United States
Sponsor
M.D. Anderson Cancer Center
View Trial →
ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology