NCT04524585 Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure
| NCT ID | NCT04524585 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Health Network, Toronto |
| Condition | Respiratory Insufficiency |
| Study Type | INTERVENTIONAL |
| Enrollment | 23 participants |
| Start Date | 2020-10-01 |
| Primary Completion | 2026-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 23 participants in total. It began in 2020-10-01 with a primary completion date of 2026-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
PNEUMA is a preliminary safety and feasibility trial of a novel approach to the titration of neuromuscular blockade (NMB) to safe spontaneous breathing in patients with moderate to severe acute hypoxemic respiratory failure (AHRF) supported with invasive mechanical ventilation.
Eligibility Criteria
Inclusion Criteria: Patients supported on invasive mechanical ventilation for moderate to severe AHRF (PaO2/FiO2 \< 150 mm Hg or FiO2 ≥ 60% with an SpO2 ≤ 97% or receiving venovenous extracorporeal membrane oxygenation) Exclusion Criteria: 1. Contraindication to neuromuscular blockade (allergy, history of malignant hyperthermia) 2. Contraindication to ulnar nerve stimulation (bilateral peripheral neuropathy, skin burns on both wrists) 3. Previous history of a formally diagnosed neuromuscular disorder
Contact & Investigator
Ewan Goligher, MD, PhD
PRINCIPAL INVESTIGATOR
University Health Network, Toronto
Frequently Asked Questions
Who can join the NCT04524585 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Respiratory Insufficiency. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04524585 currently recruiting?
Yes, NCT04524585 is actively recruiting participants. Contact the research team at glauco.plens@uhn.ca for enrollment information.
Where is the NCT04524585 trial being conducted?
This trial is being conducted at Toronto, Canada.
Who is sponsoring the NCT04524585 clinical trial?
NCT04524585 is sponsored by University Health Network, Toronto. The principal investigator is Ewan Goligher, MD, PhD at University Health Network, Toronto. The trial plans to enroll 23 participants.